Demirbilek S, Atayurt H F, Celik N, Aydin G
Department of Pediatric Surgery and Pathology, Social Security Council, Ankara Children's Hospital, Ankara, Turkey.
Pediatr Surg Int. 1997;12(8):591-4. doi: 10.1007/BF01371906.
Between May 1993 and November 1995, 71 cryptorchid boys were treated with human chorionic gonadotropin (hCG); 42 were operated upon following unsuccessful hCG treatment. A routine orchiopexy was performed in each case. In 10 cases a testicular biopsy was made during orchipexy within 3 days following hCG treatment; in another 10 biopsies were taken 6 to 9 months after treatment. Testicular biopsies were taken at the time of orchiopexy in 5 cryptorchid boys who were not treated with hCG as a control group. A mild, inflammation-like reaction was found in the cryptorchid testes in the period immediately following the last hCG injections, but those studied 6 to 9 months after the last injection there were no apparent such reactions. In contrast to the inflammation-like reaction, the volume density of blood vessels, interstitial bleeding, and diameter of the seminiferous tubules had not regressed. The numbers of spermatogonia per tubular transverse section and the percentage of tubular transverse sections containing spermatogonia (the fertility index) were increased.
1993年5月至1995年11月期间，71名隐睾男孩接受了人绒毛膜促性腺激素（hCG）治疗；42名男孩在hCG治疗失败后接受了手术。每例均进行了常规睾丸固定术。10例在hCG治疗后3天内进行睾丸固定术时取睾丸活检；另外10例在治疗后6至9个月取活检。5名未接受hCG治疗的隐睾男孩在睾丸固定术时取睾丸活检作为对照组。在最后一次注射hCG后的即刻，隐睾中发现有轻度的、类似炎症的反应，但在最后一次注射后6至9个月进行研究时，未发现明显的此类反应。与类似炎症的反应不同，血管的体积密度、间质出血和生精小管直径并未消退。每个小管横切面的精原细胞数量以及含有精原细胞的小管横切面百分比（生育指数）均增加。
