Bjarnason I, Zanelli G, Prouse P, Smethurst P, Smith T, Levi S, Gumpel M J, Levi A J
Section of Gastroenterology, MRC Clinical Research Centre, Harrow, Middlesex.
Lancet. 1987 Sep 26;2(8561):711-4. doi: 10.1016/s0140-6736(87)91075-0.
Nearly three-quarters of patients on long-term treatment with non-steroidal anti-inflammatory drugs (NSAIDs) have small-intestinal inflammation, the consequences of which are largely unknown. Two potentially important complications, blood and protein loss from the small intestine, have been studied. 49 patients on NSAIDs underwent study with an indium-111 labelled leucocyte technique which localises and measures intestinal inflammation. 32 patients underwent simultaneous study with technetium-99m labelled red blood cells (RBC), which showed identical sites of localisation to 111In-leucocytes in 19. Intestinal blood loss was measured in 8 patients by use of chromium-51 labelled RBC, and a significant correlation between blood loss and intestinal inflammation was found. Intestinal protein loss was assessed in 9 patients with 51Cr-labelled proteins; patients with NSAID-induced small-intestinal inflammation were found to have a protein-losing enteropathy. These studies show that small intestinal inflammation caused by NSAIDs is associated with blood and protein loss, both of which may contribute to the general ill-health of rheumatic patients.
长期使用非甾体抗炎药（NSAIDs）治疗的患者中，近四分之三存在小肠炎症，但其后果大多未知。已经对两种潜在的重要并发症，即小肠失血和蛋白质丢失进行了研究。49例服用NSAIDs的患者采用铟-111标记白细胞技术进行研究，该技术可定位并测量肠道炎症。32例患者同时采用锝-99m标记红细胞（RBC）进行研究，其中19例显示与铟-111标记白细胞的定位部位相同。8例患者使用铬-51标记红细胞测量肠道失血，发现失血与肠道炎症之间存在显著相关性。9例患者使用铬-51标记蛋白质评估肠道蛋白质丢失；发现NSAIDs引起小肠炎症的患者存在蛋白丢失性肠病。这些研究表明，NSAIDs引起的小肠炎症与失血和蛋白质丢失有关，这两者都可能导致风湿性患者的整体健康状况不佳。
