Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Department of Pulmonology and Tuberculosis, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Am J Transplant. 2018 Mar;18(3):684-695. doi: 10.1111/ajt.14492. Epub 2017 Oct 12.
During the last three decades lung transplantation (LTx) has become a proven modality for increasing both survival and health-related quality of life (HRQoL) in patients with various end-stage lung diseases. Most previous studies have reported improved HRQoL shortly after LTx. With regard to long-term effects on HRQoL, however, the evidence is less solid. This prospective cohort study was started with 828 patients who were on the waiting list for LTx. Then, in a longitudinal follow-up, 370 post-LTx patients were evaluated annually for up to 15 years. For all wait-listed and follow-up patients, the following four HRQoL instruments were administered: State-Trait Anxiety Inventory, Zung Self-rating Depression Scale, Nottingham Health Profile, and a visual analogue scale. Cross-sectional and generalized estimating equation (GEE) analysis for repeated measures were performed to assess changes in HRQoL during follow-up. After LTx, patients showed improvement in all HRQoL domains except pain, which remained steady throughout the long-term follow-up. The level of anxiety and depressive symptoms decreased significantly and remained constant. In conclusion, this study showed that HRQoL improves after LTx and tends to remain relatively constant for the entire life span.
在过去的三十年中，肺移植（LTx）已成为一种行之有效的方法，可以提高各种终末期肺部疾病患者的生存率和健康相关生活质量（HRQoL）。大多数先前的研究报告称，LTx 后 HRQoL 得到了改善。然而，关于对 HRQoL 的长期影响，证据并不充分。这项前瞻性队列研究最初纳入了 828 名等待 LTx 的患者。然后，在纵向随访中，对 370 名 LTx 后的患者进行了每年一次的评估，最长可达 15 年。对于所有等待名单和随访患者，都使用了以下四种 HRQoL 工具进行评估：状态特质焦虑量表、Zung 自评抑郁量表、诺丁汉健康量表和视觉模拟量表。进行了横截面和广义估计方程（GEE）分析，以评估随访期间 HRQoL 的变化。LTx 后，患者除了疼痛外，所有 HRQoL 领域均得到改善，而疼痛在整个长期随访过程中保持稳定。焦虑和抑郁症状的水平显著下降并保持稳定。总之，这项研究表明，LTx 后 HRQoL 得到改善，并在整个生命周期中趋于保持相对稳定。
