红细胞作为糖尿病与阿尔茨海默病之间的潜在联系。
Erythrocytes as Potential Link between Diabetes and Alzheimer's Disease.
作者信息
Carelli-Alinovi Cristiana, Misiti Francesco
机构信息
School of Medicine, Biochemistry and Clinical Biochemistry Institute, Università Cattolica del Sacro CuoreRome, Italy.
Human, Social and Health Department, University of Cassino and Lazio MeridionaleCassino, Italy.
出版信息
Front Aging Neurosci. 2017 Aug 25;9:276. doi: 10.3389/fnagi.2017.00276. eCollection 2017.
Abstract
Many studies support the existence of an association between type 2 diabetes (T2DM) and Alzheimer's disease (AD). In AD, in addition to brain, a number of peripheral tissues and cells are affected, including red blood cell (RBC) and because there are currently no reliable diagnostic biomarkers of AD in the blood, a gradually increasing attention has been given to the study of RBC's alterations. Recently it has been evidenced in diabetes, RBC alterations superimposable to the ones occurring in AD RBC. Furthermore, growing evidence suggests that oxidative stress plays a pivotal role in the development of RBC's alterations and vice versa. Once again this represents a further evidence of a shared pathway between AD and T2DM. The present review summarizes the two disorders, highlighting the role of RBC in the postulated common biochemical links, and suggests RBC as a possible target for clinical trials.
摘要
许多研究支持2型糖尿病（T2DM）与阿尔茨海默病（AD）之间存在关联。在AD中，除大脑外，包括红细胞（RBC）在内的许多外周组织和细胞都会受到影响，并且由于目前血液中尚无可靠的AD诊断生物标志物，因此对RBC改变的研究越来越受到关注。最近在糖尿病中已证实，RBC的改变与AD患者RBC中出现的改变相似。此外，越来越多的证据表明氧化应激在RBC改变的发生中起关键作用，反之亦然。这再次证明了AD和T2DM之间存在共同途径。本综述总结了这两种疾病，强调了RBC在假定的共同生化联系中的作用，并建议将RBC作为临床试验的可能靶点。
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