Scott John D
Research Division, Lyme Ontario, Fergus, ON, Canada.
SAGE Open Med Case Rep. 2017 Aug 29;5:2050313X17725645. doi: 10.1177/2050313X17725645. eCollection 2017.
The aim of this clinical assessment was to ascertain whether a 70-year-old Canadian patient, who had no history of out-of-country travel, had contracted a infection.
The adult human male developed constitutional symptoms, which included sweats, chills, and immobilizing fatigue, and was screened for human babesiosis. Subsequent testing included a complete panel that consisted of immunoflourescent antibody IgM and IgG, immunofluorescent antibody IgM and IgG, PCR, and fluorescent hybridization (FISH) test.
Both the IgM serology and the molecular FISH RNA probe were positive for ; all tests for were negative. Based on clinical symptoms and laboratory tests, the patient was diagnosed with human babesiosis. Interestingly, the patient's wife also was confirmed positive using serological and molecular testing.
This is the first report of a locally acquired case of human babesiosis in Canada caused by . The geographical distribution of in North America is much greater than previously anticipated, especially north of the Canada-United States border. Since the patient was bitten by a blacklegged tick, , a carrier of multiple zoonotic pathogens, the author suggests that this tick species is a vector of . Health-care providers must be aware that is present in Canada, and poses a public health risk.
本次临床评估的目的是确定一名70岁、无境外旅行史的加拿大患者是否感染了某种疾病。
该成年男性出现了全身性症状，包括盗汗、寒战和使人虚弱的疲劳，并接受了人巴贝斯虫病筛查。后续检测包括一个完整的检测项目，其中包括免疫荧光抗体IgM和IgG、免疫荧光抗体IgM和IgG、聚合酶链反应（PCR）以及荧光原位杂交（FISH）检测。
IgM血清学检测和分子FISH RNA探针检测均显示某病原体呈阳性；所有针对其他病原体的检测均为阴性。根据临床症状和实验室检测结果，该患者被诊断为人巴贝斯虫病。有趣的是，患者的妻子经血清学和分子检测也被确认为阳性。
这是加拿大首例由某病原体引起的本地获得性人巴贝斯虫病病例报告。该病原体在北美的地理分布比之前预期的要广泛得多，尤其是在加拿大 - 美国边境以北地区。由于患者被黑脚蜱叮咬，黑脚蜱是多种人畜共患病原体的携带者，作者认为这种蜱虫是该病原体的传播媒介。医疗保健人员必须意识到该病原体在加拿大存在，并构成公共卫生风险。
