Association between (rs4646994), (rs1799883), (rs1801133), (rs9939609) Genes Polymorphism and Type 2 Diabetes with Dyslipidemia.

Diabetic dyslipidemia is one of the leading causes of coronary artery disease (CAD) death. Genetic and environmental factors play an important role in the development of type 2 diabetes mellitus (T2DM) and dyslipidemia. The present study was aimed to investigate the association of (rs4646994), (rs1799883), (rs1801133) and (rs9939609) genes polymorphism in T2DM with dyslipidemia. Totally, 559 subjects including 221 T2DM cases with dyslipidemia, 158 T2DM without dyslipidemia and 180 controls were enrolled. genes polymorphism was evaluated by polymerase chain reaction (PCR), while , , genes polymorphisms were evaluated by PCR and restriction fragment length polymorphism (RFLP). Significant association of and genes polymorphisms were found in both group of cases [T2DM with dyslipidemia (P<0.001, and P=0.008, respectively) and T2DM without dyslipidemia (P=0.003, and P=0.010, respectively)] while and genes polymorphisms were significantly associated with T2DM without dyslipidemia (P=0.038, and P= 0.019, respectively). This study concludes that , , and genes are associated with T2DM. Additionally, it also seems that and genes might be further associated with the development of dyslipidemia in T2DM cases.