代谢相关基因多态性与汉族人寻常型银屑病的关联。
Association of Polymorphisms of Metabolism-Related Genes with Psoriasis Vulgaris in Han Chinese.
机构信息
Department of Dermatology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
出版信息
Biomed Res Int. 2021 Sep 18;2021:9920631. doi: 10.1155/2021/9920631. eCollection 2021.
AIM
Psoriasis is a chronic inflammatory disease with a complex etiology, and psoriasis vulgaris (PsV) is the most common type of psoriasis. Recent studies suggest the relationship between psoriasis and metabolic syndrome in different ethnicities. This study is aimed at evaluating the association of metabolism-related gene variants with the risk of PsV in Chinese Han population. . PsV patients (1030) and healthy controls (965) were enrolled in this study. Eighteen single-nucleotide polymorphisms (SNPs) previously reported to be significantly associated with metabolic syndrome were selected. SNPs were detected by next-generation sequencing.
RESULTS
Seven SNPs were significantly associated with PsV: rs805303 ( = 0.012, OR = 0.85), rs3177928 ( = 1.37 × 10, OR = 2.51), and rs2247056 ( = 3.73 × 10, OR = 0.67) located in the HLA gene region; rs1047781 ( = 0.012, OR = 1.18), rs281379 ( = 0.014, OR = 1.71), and rs492602 ( = 0.005, OR = 1.86) located in the FUT2 region; and rs2303138 ( = 0.014, OR = 1.18) located in the LNPEP region. After stratified analysis, rs805303 ( = 0.017, OR = 0.74) and rs2303138 ( = 0.041, OR = 1.30) were associated with PsVs when HLA-C06 : 02 was positive, and rs805303 ( = 5.62 × 10, OR = 0.68), rs3177928 ( = 0.003, OR = 1.75), rs281379 ( = 0.034, OR = 1.96), and rs492602 ( = 0.025, OR = 2.04) were associated with PsVs when HLA-C06 : 02 was negative.
CONCLUSION
PsV and metabolic syndrome may have overlapped susceptible genes in Chinese Han population.
目的
银屑病是一种病因复杂的慢性炎症性疾病，寻常型银屑病（PsV）是最常见的银屑病类型。最近的研究表明，银屑病与不同种族人群的代谢综合征之间存在关系。本研究旨在评估与代谢相关的基因变异与汉族人群患 PsV 的风险之间的关联。
方法
本研究纳入了 1030 例 PsV 患者和 965 例健康对照者。选择了之前报道与代谢综合征显著相关的 18 个单核苷酸多态性（SNP）。通过下一代测序检测 SNP。
结果
有 7 个 SNP 与 PsV 显著相关：位于 HLA 基因区域的 rs805303（ = 0.012，OR = 0.85）、rs3177928（ = 1.37×10，OR = 2.51）和 rs2247056（ = 3.73×10，OR = 0.67）；位于 FUT2 区域的 rs1047781（ = 0.012，OR = 1.18）、rs281379（ = 0.014，OR = 1.71）和 rs492602（ = 0.005，OR = 1.86）；以及位于 LNPEP 区域的 rs2303138（ = 0.014，OR = 1.18）。分层分析后，当 HLA-C06:02 为阳性时，rs805303（ = 0.017，OR = 0.74）和 rs2303138（ = 0.041，OR = 1.30）与 PsVs 相关，当 HLA-C06:02 为阴性时，rs805303（ = 5.62×10，OR = 0.68）、rs3177928（ = 0.003，OR = 1.75）、rs281379（ = 0.034，OR = 1.96）和 rs492602（ = 0.025，OR = 2.04）与 PsVs 相关。
结论
汉族人群中银屑病和代谢综合征可能存在重叠的易感基因。
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