Yuan Renyikun, Hou Ying, Sun Wen, Yu Jie, Liu Xin, Niu Yanan, Lu Jin-Jian, Chen Xiuping
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.
Ann N Y Acad Sci. 2017 Aug;1401(1):19-27. doi: 10.1111/nyas.13387.
Chemotherapy is the standard internal medical treatment for cancer. However, the resistance of cancer cells to nearly all kinds of chemotherapeutic drugs and targeted drugs has become prevalent, and approximately 80-90% of deaths in cancer patients are directly or indirectly attributed to drug resistance. The progress of new drug research and development has also been impeded by the occurrence of drug resistance, which has emerged as a considerable challenge in cancer therapy. Fortunately, natural products with diverse chemical structures and pharmacological effects serve as effective substances against drug resistance. Since the discovery of a series of drug-resistant proteins, drug-efflux inhibition has been applied as the primary strategy to overcome drug resistance by maintaining the intracellular concentrations of chemotherapeutic drugs. Nonapoptotic cell death is considered an alternative strategy because most cases of drug resistance result in evasion and insensitivity to apoptosis. In this concise review, we summarize two strategies using natural products against drug resistance.
化疗是癌症的标准内科治疗方法。然而，癌细胞对几乎所有种类的化疗药物和靶向药物产生耐药性的情况已很普遍，癌症患者中约80-90%的死亡直接或间接归因于耐药性。耐药性的出现也阻碍了新药研发的进展，这已成为癌症治疗中的一个重大挑战。幸运的是，具有多样化学结构和药理作用的天然产物可作为对抗耐药性的有效物质。自从发现一系列耐药蛋白以来，药物外排抑制已作为通过维持化疗药物细胞内浓度来克服耐药性的主要策略。非凋亡性细胞死亡被认为是一种替代策略，因为大多数耐药情况会导致对凋亡的逃避和不敏感。在这篇简要综述中，我们总结了利用天然产物对抗耐药性的两种策略。
