Department of Psychiatry and Biobehavioral Sciences, University of California.
Department of Neurology, University of California.
Neuropsychology. 2018 Feb;32(2):206-212. doi: 10.1037/neu0000390. Epub 2017 Sep 11.
Recent studies suggest that intraindividual variability (IIV) of neuropsychological performance may be sensitive to HIV-associated neurologic compromise. IIV may be particularly dependent upon the integrity of frontal-subcortical systems, and therefore may be a meaningful phenotype in HIV. We examined the relationship between change in IIV and white matter integrity among HIV seropositive (HIV+) and HIV seronegative (HIV-) individuals.
The sample consisted of 38 HIV+ participants and 26 HIV- control participants who underwent neuroimaging and a neuropsychological evaluation at baseline and at 2-year follow-up evaluation.
Among HIV+ participants, increases in IIV (greater dispersion) were related to lower fractional anisotropy (FA) values in the anterior thalamic radiations (ATR) and the superior longitudinal fasciculus (SLF). Changes in mean-level global cognitive functioning were not significantly related to white matter integrity. Additionally, there was a significant Group × IIV interaction effect in the SLF demonstrating that the relationship between IIV and white matter integrity was specific to HIV.
Overall, findings suggest that IIV may be more sensitive, relative to mean-level global cognitive functioning, in the detection of neurologic compromise among HIV+ individuals. (PsycINFO Database Record
最近的研究表明，神经心理学表现的个体内变异性（IIV）可能对与 HIV 相关的神经功能障碍敏感。IIV 可能特别依赖于额皮质下系统的完整性，因此可能是 HIV 中的一个有意义的表型。我们研究了 HIV 阳性（HIV+）和 HIV 阴性（HIV-）个体的 IIV 变化与白质完整性之间的关系。
该样本由 38 名 HIV+参与者和 26 名 HIV-对照参与者组成，他们在基线和 2 年随访评估时接受了神经影像学和神经心理学评估。
在 HIV+参与者中，IIV 的增加（更大的离散度）与前丘脑辐射（ATR）和上纵束（SLF）的分数各向异性（FA）值降低有关。平均水平的整体认知功能变化与白质完整性没有显著相关。此外，SLF 中存在显著的组×IIV 交互效应，表明 IIV 与白质完整性之间的关系是 HIV 特有的。
总体而言，研究结果表明，与平均水平的整体认知功能相比，IIV 可能更敏感，能够检测 HIV+个体的神经功能障碍。
