Chen Yanxian, Xiao Ou, Guo Xinxing, Wang Decai, Sankaridurg Padmaja, Morgan Ian, He Mingguang
a State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center , Sun Yat-sen University , Guangzhou , China.
b Brien Holden Vision Institute , Sydney , Australia.
Ophthalmic Epidemiol. 2018 Feb;25(1):31-38. doi: 10.1080/09286586.2017.1338733. Epub 2017 Sep 11.
The increasing prevalence of high myopia and its associated pathologies has raised challenges to ophthalmic services. This project aims to explore the onset and progression of myopic pathologies in highly myopic eyes through a prospective research cohort established in South China.
Patients with high myopia (sphere ≤ -6.00 D) visiting the optometric clinic of Zhongshan Ophthalmic Center (ZOC) were invited to participate in the baseline examinations and follow-up visit over a 10-year period. People having secondary myopia, history of any refractive surgery, significant ocular media opacity, or other severe health problems were excluded. The measurements included visual acuity, ocular biometry, visual function, cycloplegic refraction, fundus imaging, ocular shape by MRI, blood tests and questionnaires.
A total of 890 participants completed the baseline examinations, with a mean age at baseline of 22.7 ± 12.4 years. The mean spherical equivalent at baseline was 10.13 ± 3.65 D, and the mean axial length (AL) was 27.52 ± 1.63 mm. The older subjects tended to have more severe myopia and longer ALs.
The study will provide new knowledge on the relationship between high myopia and pathological changes such as myopic macular degeneration and staphyloma.
高度近视及其相关病变的患病率不断上升，给眼科服务带来了挑战。本项目旨在通过在中国南方建立的前瞻性研究队列，探索高度近视眼中近视病变的发病和进展情况。
邀请到中山眼科中心验光门诊就诊的高度近视患者（球镜度数≤-6.00D）参加为期10年的基线检查和随访。排除继发性近视、有任何屈光手术史、明显的眼介质混浊或其他严重健康问题的人群。测量项目包括视力、眼部生物测量、视觉功能、散瞳验光、眼底成像、MRI测量眼轴形态、血液检查和问卷调查。
共有890名参与者完成了基线检查，基线时的平均年龄为22.7±12.4岁。基线时的平均等效球镜度数为10.13±3.65D，平均眼轴长度（AL）为27.52±1.6 mm。年龄较大的受试者往往近视程度更严重，眼轴更长。
该研究将为高度近视与近视性黄斑变性、葡萄肿等病理变化之间的关系提供新知识。
