a School of Pharmaceutical Sciences , São Paulo State University (UNESP) , Araraquara , Sao Paulo , Brazil.
Crit Rev Anal Chem. 2018 Jan 2;48(1):66-72. doi: 10.1080/10408347.2017.1374165. Epub 2017 Oct 30.
Diabetes mellitus (DM) is considered a public health problem. The initial treatment consists of improving the lifestyle and making changes in the diet. When these changes are not enough, the use of medication becomes necessary. The metformin aims to reduce the hepatic production of glucose and is the preferred treatment for type 2. The objective is to survey the characteristics and properties of metformin, as well as hold a discussion on the existing analytical methods to green chemistry and their impacts for both the operator and the environment. For the survey, data searches were conducted by scientific papers in the literature as well as in official compendium. The characteristics and properties are shown, also, methods using liquid chromatography techniques, titration, absorption spectrophotometry in the ultraviolet and the infrared region. Most of the methods presented are not green chemistry oriented. It is necessary the awareness of everyone involved in the optimization of the methods applied through the implementation of green chemistry to determine the metformin.
糖尿病（DM）被认为是一个公共卫生问题。初始治疗包括改善生活方式和改变饮食。当这些改变还不够时，就需要使用药物治疗。二甲双胍旨在减少肝脏葡萄糖的产生，是治疗 2 型糖尿病的首选药物。目的是调查二甲双胍的特性和性质，并对现有的分析方法进行讨论，以了解其对操作人员和环境的影响。为此，通过文献中的科学论文以及官方纲要进行了数据检索。展示了特性和性质，还展示了使用液相色谱技术、滴定、紫外和红外区域吸收分光光度法的方法。所提出的方法大多不是绿色化学方法。有必要让所有参与方法优化的人都意识到通过实施绿色化学来确定二甲双胍的重要性。
