Peng Qingyun, Huang Wenjia, Zhang Xiao, Pang Xiaoyan, Liu Yunan, Ruan Wu, Li Qun, Ding Li, Jin Huizi, Yang Dehua, Wang Junfeng, Wang Ming-Wei
Research Center for Deepsea Bioresources, Sanya, Hainan 572025, China.
School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.
ACS Omega. 2025 Feb 5;10(6):6201-6209. doi: 10.1021/acsomega.4c11083. eCollection 2025 Feb 18.
Two new tetraene lactone derivatives ( and ), two new α-pyrone derivatives ( and ), three compounds reported as natural products for the first time [an α-pyrone derivative (), an indole-diketopiperazine alkaloid (), and a β-amino acid derivative ()], and 11 known compounds (, -), were obtained from microorganisms isolated from hadal trench sediments in the Pacific Ocean. Their structures were determined using NMR, HRESIMS, optical rotatory dispersion (ORD) spectra, NMR calculations followed by DP4+ analysis, electronic circular dichroism (ECD) calculations, X-ray crystallography analysis, and advanced Marfey's and modified Mosher eater methods. Microbial broth dilution assay suggested that compounds - and had weak antibacterial effects.
从太平洋超深渊海沟沉积物中分离出的微生物中获得了两种新的四烯内酯衍生物（和）、两种新的α-吡喃酮衍生物（和）、三种首次报道为天然产物的化合物[一种α-吡喃酮衍生物（）、一种吲哚-二酮哌嗪生物碱（）和一种β-氨基酸衍生物（）]以及11种已知化合物（，-）。通过核磁共振（NMR）、高分辨电喷雾电离质谱（HRESIMS）、旋光色散（ORD）光谱、NMR计算及DP4+分析、电子圆二色（ECD）计算、X射线晶体学分析以及先进的马尔费方法和改良的莫舍尔酯法确定了它们的结构。微生物肉汤稀释试验表明，化合物-和具有较弱的抗菌作用。
