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伪装成恶性肿瘤的动脉瘤样骨囊肿实性变体

Solid Variant of Aneurysmal Bone Cyst Masquerading as Malignancy.

作者信息

Singh Ashok, Majeed Abdul, Mallick Supriya, Khan Shah Alam, Mridha Asit Ranjan

机构信息

Assistant Professor, Department of Pathology, ANIIMS, Port Blair, Andaman and Nicobar Islands, India.

Senior Reisdent, Department of Orthopaedics, AIIMS, New Delhi, India.

出版信息

J Clin Diagn Res. 2017 Jul;11(7):ED35-ED36. doi: 10.7860/JCDR/2017/25950.10306. Epub 2017 Jul 1.

DOI:10.7860/JCDR/2017/25950.10306
PMID:28892920
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5583895/
Abstract

Solid Variant of Aneurysmal Bone Cyst (SVABC) is an uncommon neoplasm seen in young patients. The lesion presents clinically as well as on radiology like a malignant bone tumour. The aggressive features in most of the cases lead to a wrong diagnosis. Radiologically, it is expansile osteolytic with cortical breach being seen in many of the cases. We report two cases of SVABC which were misdiagnosed as malignant bone tumours. Both cases were seen in long bones. Radiologically both lesions were expansile, osteolytic, solid cystic, with destruction of cortex and were diagnosed as osteosarcomas. Both the cases were referred to us for further management and were subsequently diagnosed as SVABC. Being extremely rare these tumours have a high chance of getting misdiagnosed and knowledge of this entity along with close correlation with clinical, radiological and histopathological findings plays a critical role in accurately diagnosing this condition. An accurate diagnosis is of utmost importance as this changes the treatment drastically avoiding mutilating surgeries and unnecessary chemo radiotherapy.

摘要

动脉瘤样骨囊肿实性变体(SVABC)是一种在年轻患者中少见的肿瘤。该病变在临床及影像学上表现类似恶性骨肿瘤。大多数病例的侵袭性特征导致误诊。在影像学上,它呈膨胀性溶骨性,许多病例可见皮质破坏。我们报告两例被误诊为恶性骨肿瘤的SVABC。两例均发生于长骨。影像学上,两个病变均呈膨胀性、溶骨性、实性囊性,伴有皮质破坏,被诊断为骨肉瘤。两例均转诊至我们处进一步治疗,随后被诊断为SVABC。由于这些肿瘤极为罕见,很有可能被误诊,了解该实体并将其与临床、影像学和组织病理学发现紧密关联,对于准确诊断这种疾病起着关键作用。准确诊断至关重要,因为这会极大地改变治疗方式,避免致残性手术和不必要的放化疗。

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本文引用的文献

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Solid variant of aneurysmal bone cyst of the rib presenting as a left intrathoracic mass without radiological bone destruction.肋骨动脉瘤样骨囊肿实性变体表现为左胸腔内肿块,无放射学骨质破坏。
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USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts.USP6和CDH11癌基因可识别原发性动脉瘤样骨囊肿中的肿瘤细胞,而在所谓的继发性动脉瘤样骨囊肿中则不存在。
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