Bertoni F, Bacchini P, Capanna R, Ruggieri P, Biagini R, Ferruzzi A, Bettelli G, Picci P, Campanacci M
Ospedale Malpighi, Bologna, Italy.
Cancer. 1993 Feb 1;71(3):729-34. doi: 10.1002/1097-0142(19930201)71:3<729::aid-cncr2820710313>3.0.co;2-0.
Of the 200 cases of ABC in the Rizzoli Institute files, 15 had solid features on both gross and histologic examination. Inasmuch as fibrous proliferation with giant cell and bone production along with fibromyxoid areas and small aneurysmal spaces were found in the solid parts of the aneurysmal bone cyst, a grossly solid and radiographically osteolytic bone lesion with these microscopic features was called a solid aneurysmal bone cyst. Some authors call the same lesion extragnathic giant cell reparative granuloma.
Sixty percent of the patients were female. The metaphysis was the preferred location in the long bones (8/11). Radiographic appearance was not specific, and sometimes a malignant lesion was very difficult to rule out. In seven patients, the lesion was considered radiographically "aggressive." Intralesional excision (curettage) in 12 patients and marginal resection in 3 patients with diaphyseal location was effective in controlling the lesion. No recurrence was detected after a mean follow-up of 59 months.
High proliferative activity of the benign-appearing proliferative spindle cells, often with fairly abundant mitoses, associated with benign giant cells and immature bone production are the features of this pseudosarcomatous hyperplastic lesion. It is sometimes is mistaken for a malignant tumor.
在里佐利研究所档案中的200例骨动脉瘤样骨囊肿病例中，有15例在大体和组织学检查中均具有实性特征。鉴于在动脉瘤样骨囊肿的实性部分发现有伴有巨细胞和骨形成的纤维增生以及纤维黏液样区域和小动脉瘤样间隙，具有这些微观特征的大体实性且影像学上呈溶骨性的骨病变被称为实性动脉瘤样骨囊肿。一些作者将同一病变称为颌骨外巨细胞修复性肉芽肿。
60%的患者为女性。长骨干骺端是长骨中最常受累的部位（11例中有8例）。影像学表现不具有特异性，有时很难排除恶性病变。在7例患者中，病变在影像学上被认为具有“侵袭性”。12例行病灶内切除（刮除术），3例位于骨干的患者行边缘性切除，均有效地控制了病变。平均随访59个月后未发现复发。
这种假肉瘤样增生性病变的特征是良性增生性梭形细胞具有较高的增殖活性，通常伴有相当丰富的有丝分裂，伴有良性巨细胞和未成熟骨形成。它有时会被误诊为恶性肿瘤。
