College of Materials and Chemical Engineering, Hainan University, Haikou, 570228, China.
College of Materials and Chemical Engineering, Hainan University, Haikou, 570228, China.
Int J Biol Macromol. 2018 Jan;106:418-424. doi: 10.1016/j.ijbiomac.2017.08.038. Epub 2017 Aug 10.
In this study, cholesteryl-grafted sodium alginate derivatives (CSAD) with different molecular weights were synthesized by esterification. The structure of CSAD was confirmed by FT-IR and H NMR spectrometers. The effects of pH and CSAD polymer concentration on the self-assembled behavior and particle size of CSAD were investigated by fluorescence measurement (FM) and dynamic light scattering (DLS). In the presence of Ca, the cholesteryl-grafted sodium alginate derivative was used for fabricating self-assembled nanoparticles that can effectively encapsulate the drug acetamiprid. The drug-loaded nanoparticles were characterized by transmission electron microscopy (TEM). The encapsulation efficiency (EE) and acetamiprid drug release behavior from the nanoparticles were also studied. The results reveal that CSAD self-assembled nanoparticles had a diameter of 100nm and were nonaggregated in aqueous media; Moreover, the encapsulation efficiency and the release behavior of nanoparticles were influenced by the MW of CSAD. The mechanism of acetamiprid release was found to vary from non-Fickian (anomalous) to Fickian transport with a decrease in the molecular weight of CSAD.
在这项研究中，通过酯化反应合成了具有不同分子量的胆甾基接枝海藻酸钠衍生物（CSAD）。通过傅里叶变换红外光谱仪（FT-IR）和核磁共振光谱仪（H NMR）确认了 CSAD 的结构。通过荧光测量（FM）和动态光散射（DLS）研究了 pH 值和 CSAD 聚合物浓度对 CSAD 自组装行为和粒径的影响。在 Ca 的存在下，将胆甾基接枝的海藻酸钠衍生物用于制备可以有效包封药物啶虫脒的自组装纳米颗粒。通过透射电子显微镜（TEM）对载药纳米颗粒进行了表征。还研究了载药纳米颗粒的包封效率（EE）和啶虫脒的药物释放行为。结果表明，CSAD 自组装纳米颗粒的直径为 100nm，在水介质中无聚集；此外，MWCSAD 影响纳米颗粒的包封效率和释放行为。发现啶虫脒的释放机制从非菲克（异常）到菲克扩散随 CSAD 分子量的降低而变化。
