Department of Neurosurgery, University of Illinois at Chicago, 912 South Wood Street, MC 799, 4N NPI, Chicago, IL 60612, United States; College of Medicine, University of Illinois at Chicago, 912 South Wood Street, MC 799, 4N NPI, Chicago, IL 60612, United States.
Department of Neurosurgery, University of Illinois at Chicago, 912 South Wood Street, MC 799, 4N NPI, Chicago, IL 60612, United States.
Neurosci Biobehav Rev. 2017 Dec;83:540-546. doi: 10.1016/j.neubiorev.2017.09.007. Epub 2017 Sep 8.
Evaluating functional performance of spinal cord injury (SCI) rat models is essential for the development of novel treatments and breakthroughs. However, due to the variety of functional analysis methods available - each with its own strengths and weaknesses - it can be challenging to choose the most appropriate functional analysis test for the animal model. Therefore, we analyzed the strengths and weaknesses of five methods in order to determine which test is not only accurate and easily reproducible, but also relatively inexpensive so that it can be adopted universally. When comparing the Basso, Beattie, and Bresnahan (BBB) test, Ladder walking test, CatWalk test, Rotating Rod test, Microsoft Kinect system and VICON, we used the criteria of sensitivity, quality of data generated, statistical analysis of data, and rate of human error. These specific tests were chosen in order to compare the advantages and disadvantages of simple yet effective methods (BBB, Ladder test, and Rotating Rod test) to more complex and computerized methods (Catwalk, Microsoft Kinect and VICON).
评估脊髓损伤（SCI）大鼠模型的功能表现对于新疗法和突破的发展至关重要。然而，由于有多种功能分析方法可供选择，每种方法都有其自身的优势和劣势，因此选择最适合动物模型的功能分析测试可能具有挑战性。因此，我们分析了这五种方法的优缺点，以确定哪种测试不仅准确且易于重现，而且相对便宜，以便能够普遍采用。在比较 Basso、Beattie 和 Bresnahan（BBB）测试、梯级行走测试、CatWalk 测试、旋转棒测试、Microsoft Kinect 系统和 VICON 时，我们使用了灵敏度、生成数据的质量、数据的统计分析以及人为错误率等标准。选择这些特定的测试是为了比较简单有效的方法（BBB、梯级测试和旋转棒测试）与更复杂和计算机化的方法（CatWalk、Microsoft Kinect 和 VICON）的优缺点。
