Sunderland T, Rubinow D R, Tariot P N, Cohen R M, Newhouse P A, Mellow A M, Mueller E A, Murphy D L
Unit on Geriatric Psychopharmacology, NIMH, Bethesda, MD 20892.
Am J Psychiatry. 1987 Oct;144(10):1313-6. doi: 10.1176/ajp.144.10.1313.
Somatostatin-like immunoreactivity was measured in the CSF of 12 patients with Alzheimer's disease, 15 age-matched control subjects, and 20 older depressed subjects. Patients with dementia or depression were found to have lower CSF somatostatin concentrations than control subjects despite markedly different clinical presentations. Severity of depression was clearly different in all three groups but showed no significant correlation with CSF concentration of somatostatin. There was a significant positive correlation between CSF somatostatin-like immunoreactivity and cognitive functioning in all 47 subjects, but this association was not statistically significant within individual diagnostic groups. These data raise interesting questions about possible biological links between Alzheimer's disease and depression in older patients.
在12例阿尔茨海默病患者、15例年龄匹配的对照受试者以及20例老年抑郁症患者的脑脊液中测量了生长抑素样免疫反应性。尽管临床表现明显不同，但痴呆或抑郁症患者的脑脊液生长抑素浓度低于对照受试者。三组患者的抑郁严重程度明显不同，但与脑脊液生长抑素浓度无显著相关性。在所有47名受试者中，脑脊液生长抑素样免疫反应性与认知功能之间存在显著正相关，但在各个诊断组内这种关联无统计学意义。这些数据提出了关于老年患者阿尔茨海默病与抑郁症之间可能的生物学联系的有趣问题。
