Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
Antimicrob Agents Chemother. 2017 Oct 24;61(11). doi: 10.1128/AAC.01495-17. Print 2017 Nov.
Antibiotic use is the main driver in the emergence of antibiotic resistance. Another unexplored possibility is that resistance evolves coincidentally in response to other selective pressures. We show that selection in the absence of antibiotics can coselect for decreased susceptibility to several antibiotics. Thus, genetic adaptation of bacteria to natural environments may drive resistance evolution by generating a pool of resistance mutations that selection could act on to enrich resistant mutants when antibiotic exposure occurs.
抗生素的使用是抗生素耐药性出现的主要驱动因素。另一个尚未探索的可能性是，耐药性是偶然进化的，以应对其他选择压力。我们表明，在没有抗生素的情况下选择可以共同选择对几种抗生素的敏感性降低。因此，细菌对自然环境的遗传适应可能会通过产生一个耐药突变库来驱动耐药性进化，当抗生素暴露发生时，选择可以作用于这个突变库来富集耐药突变体。
