解读阿尔茨海默病
: Deciphering Alzheimer's Disease.
作者信息
Tan Florence Hui Ping, Azzam Ghows
机构信息
School of Biological Sciences, Universiti Sains Malaysia, 11800 USM, Pulau Pinang, Malaysia.
出版信息
Malays J Med Sci. 2017 Mar;24(2):6-20. doi: 10.21315/mjms2017.24.2.2. Epub 2017 Apr 14.
Abstract
Alzheimer's disease (AD) is the most widespread neurodegenerative disorder worldwide. Its pathogenesis involves two hallmarks: aggregation of amyloid beta (Aβ) and occurrence of neurofibrillary tangles (NFTs). The mechanism behind the disease is still unknown. This has prompted the use of animal models to mirror the disease. The fruit fly, has garnered considerable attention as an organism to recapitulate human disorders. With the ability to monopolise a multitude of traditional and novel genetic tools, is ideal for studying not only cellular aspects but also physiological and behavioural traits of human neurodegenerative diseases. Here, we discuss the use of the model in understanding AD pathology and the insights gained in discovering drug therapies for AD.
摘要
阿尔茨海默病（AD）是全球最普遍的神经退行性疾病。其发病机制涉及两个标志：β淀粉样蛋白（Aβ）的聚集和神经原纤维缠结（NFTs）的出现。该疾病背后的机制仍然未知。这促使人们使用动物模型来模拟这种疾病。果蝇作为一种能够概括人类疾病的生物体，已引起了相当大的关注。凭借其能够独占众多传统和新型遗传工具的能力，果蝇不仅非常适合研究人类神经退行性疾病的细胞层面，还适合研究其生理和行为特征。在此，我们讨论果蝇模型在理解AD病理学方面的应用以及在发现AD药物疗法中所获得的见解。
相似文献
1
: Deciphering Alzheimer's Disease.解读阿尔茨海默病
Malays J Med Sci. 2017 Mar;24(2):6-20. doi: 10.21315/mjms2017.24.2.2. Epub 2017 Apr 14.
2
Exploring the efficient natural products for Alzheimer's disease therapy via (fruit fly) models.通过（果蝇）模型探索阿尔茨海默病治疗的有效天然产物。
J Drug Target. 2023 Sep;31(8):817-831. doi: 10.1080/1061186X.2023.2245582. Epub 2023 Aug 10.
3
Pharmacological Treatment of Alzheimer's Disease: Insights from .阿尔茨海默病的药物治疗：. 的见解
Int J Mol Sci. 2020 Jun 29;21(13):4621. doi: 10.3390/ijms21134621.
4
Behavioural Effects and RNA-seq Analysis of Aβ42-Mediated Toxicity in a Drosophila Alzheimer's Disease Model.Aβ42 介导的毒性对果蝇阿尔茨海默病模型的行为影响及 RNA-seq 分析。
Mol Neurobiol. 2023 Aug;60(8):4716-4730. doi: 10.1007/s12035-023-03368-x. Epub 2023 May 5.
5
Alzheimer's Disease Model System Using Drosophila.利用果蝇建立阿尔茨海默病模型系统。
Adv Exp Med Biol. 2018;1076:25-40. doi: 10.1007/978-981-13-0529-0_3.
6
Insights from on Aβ- and tau-induced mitochondrial dysfunction: mechanisms and tools.关于Aβ和tau蛋白诱导的线粒体功能障碍的见解：机制与工具
Front Neurosci. 2023 Apr 17;17:1184080. doi: 10.3389/fnins.2023.1184080. eCollection 2023.
7
Modeling the complex pathology of Alzheimer's disease in Drosophila.在果蝇中模拟阿尔茨海默病的复杂病理。
Exp Neurol. 2015 Dec;274(Pt A):58-71. doi: 10.1016/j.expneurol.2015.05.013. Epub 2015 May 27.
8
Neuroprotective Effects of PARP Inhibitors in Models of Alzheimer's Disease.聚腺苷二磷酸核糖聚合酶抑制剂在阿尔茨海默病模型中的神经保护作用。
Cells. 2022 Apr 9;11(8):1284. doi: 10.3390/cells11081284.
9
Insights from Drosophila melanogaster model of Alzheimer's disease.阿尔茨海默病的果蝇模型研究进展。
Front Biosci (Landmark Ed). 2020 Jan 1;25(1):134-146. doi: 10.2741/4798.
10
Mapping pathogenic processes contributing to neurodegeneration in Drosophila models of Alzheimer's disease.绘制导致阿尔茨海默病果蝇模型神经退行性变的致病过程图谱。
FEBS Open Bio. 2020 Mar;10(3):338-350. doi: 10.1002/2211-5463.12773. Epub 2020 Jan 22.
引用本文的文献
1
Alzheimer's Disease: Cellular and Pharmacological Aspects.阿尔茨海默病：细胞与药理学方面
Geriatrics (Basel). 2024 Jun 22;9(4):86. doi: 10.3390/geriatrics9040086.
2
A comprehensive review on the progress and challenges of tetrahydroisoquinoline derivatives as a promising therapeutic agent to treat Alzheimer's disease.关于四氢异喹啉衍生物作为治疗阿尔茨海默病的一种有前景的治疗药物的进展与挑战的综合综述。
Heliyon. 2024 May 15;10(10):e30788. doi: 10.1016/j.heliyon.2024.e30788. eCollection 2024 May 30.
3
oil exhibits anti-aging effects in transgenic Alzheimer's via anti oxidant pathways: survival-rate and life span studies.油通过抗氧化途径在转基因阿尔茨海默病模型中展现出抗衰老作用：存活率和寿命研究
Toxicol Res (Camb). 2024 Feb 9;13(1):tfae017. doi: 10.1093/toxres/tfae017. eCollection 2024 Feb.
4
Behavioural Effects and RNA-seq Analysis of Aβ42-Mediated Toxicity in a Drosophila Alzheimer's Disease Model.Aβ42 介导的毒性对果蝇阿尔茨海默病模型的行为影响及 RNA-seq 分析。
Mol Neurobiol. 2023 Aug;60(8):4716-4730. doi: 10.1007/s12035-023-03368-x. Epub 2023 May 5.
5
Towards early detection of neurodegenerative diseases: A gut feeling.迈向神经退行性疾病的早期检测：一种直觉。
Front Cell Dev Biol. 2023 Feb 7;11:1087091. doi: 10.3389/fcell.2023.1087091. eCollection 2023.
6
Animal models of Alzheimer's disease: Applications, evaluation, and perspectives.阿尔茨海默病动物模型：应用、评估与展望。
Zool Res. 2022 Nov 18;43(6):1026-1040. doi: 10.24272/j.issn.2095-8137.2022.289.
7
Applications of Immunomagnetic Reduction Technology as a Biosensor in Therapeutic Evaluation of Chinese Herbal Medicine in Tauopathy Alleviation of an AD Model.免疫磁珠还原技术在中药治疗阿尔茨海默病模型tauopathy 中的生物传感器应用评估。
Biosensors (Basel). 2022 Oct 17;12(10):883. doi: 10.3390/bios12100883.
8
First insights into the honey bee () brain lipidome and its neonicotinoid-induced alterations associated with reduced self-grooming behavior.初探蜜蜂（ ）脑脂质组及其与减少自我梳理行为相关的新烟碱类杀虫剂诱导的变化。
J Adv Res. 2021 Aug 13;37:75-89. doi: 10.1016/j.jare.2021.08.007. eCollection 2022 Mar.
9
Neuroprotective Effects of PARP Inhibitors in Models of Alzheimer's Disease.聚腺苷二磷酸核糖聚合酶抑制剂在阿尔茨海默病模型中的神经保护作用。
Cells. 2022 Apr 9;11(8):1284. doi: 10.3390/cells11081284.
10
Neurotherapy of Yi-Gan-San, a Traditional Herbal Medicine, in an Alzheimer's Disease Model of by Alleviating Aβ Expression.传统草药一贯煎对阿尔茨海默病模型的神经治疗作用：通过减轻β-淀粉样蛋白表达
Plants (Basel). 2022 Feb 21;11(4):572. doi: 10.3390/plants11040572.
本文引用的文献
1
2016 Alzheimer's disease facts and figures.2016 年阿尔茨海默病事实和数据。
Alzheimers Dement. 2016 Apr;12(4):459-509. doi: 10.1016/j.jalz.2016.03.001.
2
Argonaute: The executor of small RNA function.Argonaute：小RNA功能的执行者。
J Genet Genomics. 2016 Aug 20;43(8):481-94. doi: 10.1016/j.jgg.2016.06.002. Epub 2016 Jun 30.
3
World Brain Day 2016: celebrating brain health in an ageing population.2016年世界脑卒中日：在老龄化人口中倡导脑健康
Lancet Neurol. 2016 Sep;15(10):1008. doi: 10.1016/S1474-4422(16)30171-5. Epub 2016 Jul 22.
4
Neurodegeneration in a Drosophila model of adrenoleukodystrophy: the roles of the Bubblegum and Double bubble acyl-CoA synthetases.肾上腺脑白质营养不良果蝇模型中的神经退行性变：Bubblegum和Double bubble酰基辅酶A合成酶的作用
Dis Model Mech. 2016 Apr;9(4):377-87. doi: 10.1242/dmm.022244. Epub 2016 Feb 18.
5
Transgenic Drosophila model to study apolipoprotein E4-induced neurodegeneration.用于研究载脂蛋白E4诱导神经退行性变的转基因果蝇模型。
Behav Brain Res. 2016 Mar 15;301:10-8. doi: 10.1016/j.bbr.2015.12.022. Epub 2015 Dec 17.
6
The Role of miR-124 in Drosophila Alzheimer's Disease Model by Targeting Delta in Notch Signaling Pathway.通过靶向Notch信号通路中的Delta，miR-124在果蝇阿尔茨海默病模型中的作用
Curr Mol Med. 2015;15(10):980-9. doi: 10.2174/1566524016666151123114608.
7
Drosophila as an In Vivo Model for Human Neurodegenerative Disease.果蝇作为人类神经退行性疾病的活体模型。
Genetics. 2015 Oct;201(2):377-402. doi: 10.1534/genetics.115.179457.
8
Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau.微小RNA-219的失调通过对tau蛋白的转录后调控促进神经退行性变。
J Clin Invest. 2015 Feb;125(2):681-6. doi: 10.1172/JCI78421. Epub 2015 Jan 9.
9
MicroRNA expression analysis of adult-onset Drosophila Alzheimer's disease model.成年发病型果蝇阿尔茨海默病模型的微小RNA表达分析
Curr Alzheimer Res. 2014;11(9):882-91.
10
Understanding functional miRNA-target interactions in vivo by site-specific genome engineering.通过位点特异性基因组工程在体内理解功能性miRNA-靶标相互作用。
Nat Commun. 2014 Aug 19;5:4640. doi: 10.1038/ncomms5640.
Zotero 插件