Ismail Nabilah, Zam Zarifah, Hassan Siti Asma, Rahman Zaidah Abdul
Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
Hospital Taiping, Jalan Taming Sari, 34000 Taiping, Perak, Malaysia.
Malays J Med Sci. 2017 Mar;24(2):21-27. doi: 10.21315/mjms2017.24.2.3. Epub 2017 Apr 14.
has emerged as an important nosocomial pathogen, capable of causing a wide spectrum of infections. Treatment is difficult because it is resistant to many antimicrobial agents, thus reducing the treatment options. The aims of this study were to describe the antimicrobial susceptibility patterns and synergistic effect of selected antimicrobial combinations against isolates.
This was a descriptive cross-sectional study undertaken in the Hospital Universiti Sains Malaysia from April 2011 to March 2012. isolated from various clinical specimens were included in the study. Antimicrobial susceptibility testing was done using the epsilometer test (E-test) and interpreted according to the guidelines of the Clinical and Laboratory Standards Institute. In the synergy test, the isolates were tested against six different antimicrobial combinations.
In total, 84 isolates were collected and analysed. According to the E-test, the antimicrobial susceptibility of trimethoprim-sulfamethoxazole (TMP-SMX), tigecycline, and ciprofloxacin was 100%, 91.1%, and 88.9% respectively. The antimicrobial combination of TMP-SMX and ceftazidime showed the highest synergistic effect.
TMP-SMX remains the antimicrobial of choice to treat infection. TMP-SMX and ceftazidime was the most effective combination in vitro.
已成为一种重要的医院病原体，能够引起广泛的感染。由于它对许多抗菌药物耐药，治疗困难，从而减少了治疗选择。本研究的目的是描述所选抗菌药物组合对分离株的抗菌敏感性模式和协同效应。
这是一项于2011年4月至2012年3月在马来西亚理科大学医院进行的描述性横断面研究。从各种临床标本中分离出的菌株纳入研究。使用E试验（E-test）进行抗菌药物敏感性测试，并根据临床和实验室标准研究所的指南进行解释。在协同试验中，对分离株进行六种不同抗菌药物组合的测试。
总共收集并分析了84株分离株。根据E试验，甲氧苄啶-磺胺甲恶唑（TMP-SMX）、替加环素和环丙沙星的抗菌敏感性分别为100%、91.1%和88.9%。TMP-SMX与头孢他啶的抗菌组合显示出最高的协同效应。
TMP-SMX仍然是治疗感染的首选抗菌药物。TMP-SMX和头孢他啶在体外是最有效的组合。
