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人类中性粒细胞的进化及其相关疾病

Neutrophil Evolution and Their Diseases in Humans.

作者信息

Leiding Jennifer W

机构信息

Division of Allergy and Immunology, Department of Pediatrics, University of South Florida, Tampa, FL, United States.

Johns Hopkins All Children's Hospital, St. Petersburg, FL, United States.

出版信息

Front Immunol. 2017 Aug 28;8:1009. doi: 10.3389/fimmu.2017.01009. eCollection 2017.

DOI:10.3389/fimmu.2017.01009
PMID:28894446
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5581313/
Abstract

Granulocytes have been preserved and have evolved across species, developing into cells that provide one of the first lines of host defense against pathogens. In humans, neutrophils are involved in early recognition and killing of infectious pathogens. Disruption in neutrophil production, emigration, chemotaxis, and function cause a spectrum of primary immune defects characterized by host susceptibility to invasive infections.

摘要

粒细胞得以保存并在物种间进化，发展成为提供宿主抵御病原体第一道防线的细胞。在人类中，中性粒细胞参与对感染性病原体的早期识别和杀伤。中性粒细胞生成、迁移、趋化性及功能的破坏会导致一系列以宿主易患侵袭性感染为特征的原发性免疫缺陷。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bd9/5581313/0b293b4d729a/fimmu-08-01009-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bd9/5581313/09496d43c2d9/fimmu-08-01009-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bd9/5581313/0b293b4d729a/fimmu-08-01009-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bd9/5581313/09496d43c2d9/fimmu-08-01009-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bd9/5581313/0b293b4d729a/fimmu-08-01009-g002.jpg

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2
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Hyper IgM Syndrome: a Report from the USIDNET Registry.
Front Immunol. 2024 Jan 8;14:1334205. doi: 10.3389/fimmu.2023.1334205. eCollection 2023.
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Prog Neurobiol. 2023 Sep;228:102488. doi: 10.1016/j.pneurobio.2023.102488. Epub 2023 Jun 23.
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