Mohamed Gamal Baheeg, Saed Madeha Abdellah, Abdelhakeem Abdelhakeem Abdelmohsen, Salah Kalid, Saed Abdelrahman Mamdouh
MD, Professor, Department of Pediatrics, Minia University, Minia, Egypt.
Lecturer, Department of Pediatrics, Minia University, Minia, Egypt.
Electron Physician. 2017 Jul 25;9(7):4880-4885. doi: 10.19082/4880. eCollection 2017 Jul.
Pneumonia is the leading cause of death in children. Few studies have explored the predictive value of copeptin in pediatric pneumonia.
This study aimed to assess the role of copeptin as a marker of severity of community-acquired pneumonia (CAP).
This prospective case-control study was carried out at Minia University Children's Hospital in Minia (Egypt) from January to December 2016. Eighty children aged from 2 months to 42 months were enrolled in this study and were classified into group 1 (40 children with clinical, laboratory and radiological evidence of pneumonia) and group 2 (40 apparently healthy control). Serum copeptin level was assayed for all enrolled children.
Mean serum copeptin level was significantly higher in pneumonic patients (985.7±619) pg/ml compared to controls (519±308.2) pg/ml (p<0.001). Serum copeptin was significantly elevated in survivors of pneumonia more than non-survivors (p=0.001). Also, copeptin was significantly higher in the group of non-survivors (1811.8±327.1) compared to 745.4±472.5 for survivors (p=0.01). There was a significant positive correlation between serum copeptin levels and the degree of respiratory distress (p=0.02).
Copeptin seems a reliable and available predictor marker for assessing the severity and prognosis of pediatric community acquired pneumonia.
肺炎是儿童死亡的主要原因。很少有研究探讨 copeptin 在小儿肺炎中的预测价值。
本研究旨在评估 copeptin 作为社区获得性肺炎（CAP）严重程度标志物的作用。
本前瞻性病例对照研究于 2016 年 1 月至 12 月在埃及米尼亚的米尼亚大学儿童医院进行。80 名年龄在 2 个月至 42 个月的儿童参与了本研究，分为第 1 组（40 名有临床、实验室和影像学证据的肺炎患儿）和第 2 组（40 名明显健康的对照儿童）。对所有参与研究的儿童检测血清 copeptin 水平。
肺炎患者的平均血清 copeptin 水平（985.7±619）pg/ml 显著高于对照组（519±308.2）pg/ml（p<0.001）。肺炎幸存者的血清 copeptin 水平显著高于非幸存者（p=0.001）。此外，非幸存者组的 copeptin 水平（1811.8±327.1）显著高于幸存者组的 745.4±472.5（p=0.01）。血清 copeptin 水平与呼吸窘迫程度之间存在显著正相关（p=0.02）。
Copeptin 似乎是评估小儿社区获得性肺炎严重程度和预后的可靠且可用的预测标志物。
