Ang Hui Ying, Huang Ying Ying, Lim Soo Teik, Wong Philip, Joner Michael, Foin Nicolas
National Heart Centre Singapore, Singapore, Singapore.
School of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore.
J Thorac Dis. 2017 Aug;9(Suppl 9):S923-S934. doi: 10.21037/jtd.2017.06.30.
Bioresorbable scaffolds (BRS) were developed to overcome the drawbacks of current metallic drug-eluting stents (DES), such as late in-stent restenosis and caging of the vessel permanently. The concept of the BRS is to provide transient support to the vessel during healing before being degraded and resorbed by the body, freeing the vessel and restoring vasomotion. The mechanical properties of the BRS are influenced by the choice of the material and processing methods. Due to insufficient radial strength of the bioresorbable material, BRS often required large strut profile as compared to conventional metallic DES. Having thick struts will in turn affect the deliverability of the device and may cause flow disturbance, thereby increasing the incidence of acute thrombotic events. Currently, the bioresorbable poly-l-lactic acid (PLLA) polymer and magnesium (Mg) alloys are being investigated as materials in BRS technologies. The bioresorption process, mechanical properties, observations and clinical outcomes of PLLA-based and Mg-based BRS will be examined in this review.
生物可吸收支架（BRS）的研发旨在克服当前金属药物洗脱支架（DES）的缺点，如晚期支架内再狭窄和血管的永久性束缚。BRS的理念是在愈合过程中为血管提供临时支撑，随后被身体降解和吸收，使血管得以解放并恢复血管运动。BRS的机械性能受材料选择和加工方法的影响。由于生物可吸收材料的径向强度不足，与传统金属DES相比，BRS通常需要较大的支架轮廓。支架较厚反过来会影响器械的可输送性，并可能导致血流紊乱，从而增加急性血栓事件的发生率。目前，生物可吸收聚左旋乳酸（PLLA）聚合物和镁（Mg）合金正在作为BRS技术的材料进行研究。本综述将探讨基于PLLA和基于Mg的BRS的生物吸收过程、机械性能、观察结果及临床结局。
