Ferretti Mark, Saji Akhil A, Phillips John
Department of Urology, School of Medicine, New York Medical College, Valhalla, New York.
Adv Wound Care (New Rochelle). 2017 Sep 1;6(9):289-295. doi: 10.1089/wound.2017.0730.
The outcome of Fournier's gangrene (FG) may be affected by comorbidities, demographics, and choice of treatment modality. We sought to evaluate our institution's management protocol of FG measured by mortality rate (MR) and length of hospital stay (LHS) in a retrospective cohort study. A database of 20 FG cases at our institution throughout the 2009-2016 study period was assembled by a retrospective review of medical records. A Fournier's Gangrene Severity Index Score (FGSIS) was calculated for each case. Data were analyzed for statistical significance using logistic regression. The most common presentation of FG at our institution was a hyperglycemic diabetic male in his fifth decade of life with a second risk factor such as recent surgery or active malignancy. The average FGSIS was 9 overall and 14 for the mortalities. An increased FGSIS was predictive of having an increased MR or hospital stay above the median (>25 days) ( = 0.0194). The average LHS was 32 days overall, 22 days for patients treated with hyperbaric oxygen therapy and 40 days for patients treated with tangential hydrosurgery. Overall MR was 15%. This is the second known study to characterize usage of tangential hydrosurgery in the management of FG. Treatment outcomes at our institution are comparable to those reported in recent literature, a significant decline from the historical MR of 50-60%.
福尼尔坏疽(FG)的预后可能受到合并症、人口统计学特征和治疗方式选择的影响。在一项回顾性队列研究中,我们试图评估以死亡率(MR)和住院时间(LHS)衡量的本机构FG管理方案。通过对病历的回顾性审查,收集了2009 - 2016年研究期间本机构20例FG病例的数据库。为每个病例计算福尼尔坏疽严重程度指数评分(FGSIS)。使用逻辑回归分析数据的统计学意义。在本机构,FG最常见的表现是一名50多岁的高血糖糖尿病男性,伴有诸如近期手术或活动性恶性肿瘤等第二个危险因素。总体平均FGSIS为9,死亡病例为14。FGSIS升高预示着MR增加或住院时间超过中位数(>25天)(P = 0.0194)。总体平均LHS为32天,接受高压氧治疗的患者为22天,接受切线水刀手术治疗的患者为40天。总体MR为15%。这是第二项已知的描述切线水刀手术在FG管理中应用的研究。本机构的治疗结果与近期文献报道的结果相当,较历史上50 - 60%的MR有显著下降。