Department of Hematology, The First Affiliated Hospital of Nanjing Medical University/Jiangsu Province Hospital, 300 Guangzhou Road, Nanjing 210029, China.
J Immunol Res. 2017;2017:9130608. doi: 10.1155/2017/9130608. Epub 2017 Aug 15.
It is well known that cereblon is a key protein in autosomal recessive nonsyndromic mental retardation. Studies have reported that it has an intermediary role in helping immunomodulatory drugs perform their immunomodulatory and tumoricidal effects. In addition, cereblon also regulates the expression, assembly, and activities of other special proteins related to cell proliferation and metabolism, resulting in the occurrence and development of metabolic diseases. This review details the multiple functions of cereblon and the underlying mechanisms. We also put forward some unsolved problems, including the intrinsic mechanism of cereblon function and the possible regulatory mechanisms of its expression.
众所周知，cereblon 是常染色体隐性非综合征性智力低下的关键蛋白。研究表明，它在帮助免疫调节药物发挥其免疫调节和杀肿瘤作用方面发挥了中介作用。此外，cereblon 还调节与细胞增殖和代谢相关的其他特殊蛋白的表达、组装和活性，导致代谢性疾病的发生和发展。本综述详细介绍了 cereblon 的多种功能及其潜在机制。我们还提出了一些尚未解决的问题，包括 cereblon 功能的内在机制及其表达的可能调节机制。
