• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

甲氨蝶呤意外导致的慢性中毒;两例报告

Accidental Chronic Poisoning with Methotrexate; Report of Two Cases.

作者信息

Bidaki Reza, Kian Mojgan, Owliaey Hamid, Babaei Zarch Mojtaba, Feysal Masoud

机构信息

Research Center of Addiction and Behavioral Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

出版信息

Emerg (Tehran). 2017;5(1):e67. Epub 2017 May 21.

PMID:28894782
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5585837/
Abstract

Methotrexate has been used widely in dermatology, oncology and rheumatology fields. However, methotrexate-induced mucocutaneous lesions may occur in rare cases. In this case presentation, we report two cases of accidental poisoning with methotrexate. They had accidentally used methotrexate instead of digoxin. This case report emphasizes that early diagnosis and appropriate management is critical in order to improve outcome.

摘要

甲氨蝶呤已广泛应用于皮肤科、肿瘤学和风湿病学领域。然而,甲氨蝶呤引起的皮肤黏膜病变可能在罕见情况下发生。在本病例报告中,我们报告了两例甲氨蝶呤意外中毒病例。他们意外地使用了甲氨蝶呤而非地高辛。本病例报告强调,早期诊断和适当处理对于改善预后至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4882/5585837/91410fbb604b/emerg-5-e67-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4882/5585837/a7578599700f/emerg-5-e67-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4882/5585837/91410fbb604b/emerg-5-e67-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4882/5585837/a7578599700f/emerg-5-e67-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4882/5585837/91410fbb604b/emerg-5-e67-g002.jpg

相似文献

1
Accidental Chronic Poisoning with Methotrexate; Report of Two Cases.甲氨蝶呤意外导致的慢性中毒;两例报告
Emerg (Tehran). 2017;5(1):e67. Epub 2017 May 21.
2
[4pp Mucocutaneous manifestations of methotrexate toxicity].[4页 甲氨蝶呤毒性的皮肤黏膜表现]
Medicina (B Aires). 2018;78(1):50-53.
3
What can clinicians learn from therapeutic studies about the treatment of acute oral methotrexate poisoning?临床医生可以从关于急性口服甲氨蝶呤中毒治疗的治疗性研究中学到什么?
Clin Toxicol (Phila). 2017 Feb;55(2):88-96. doi: 10.1080/15563650.2016.1271126.
4
Pediatric case of accidental oral overdose of methotrexate.小儿甲氨蝶呤意外口服过量病例。
Ann Emerg Med. 1999 Jul;34(1):98-100. doi: 10.1016/s0196-0644(99)70279-9.
5
Mucocutaneous Ulcers Unmasking Severe Systemic Methotrexate Toxicity - A Case-Series and Review of Literature.黏膜皮肤溃疡揭示严重的全身性甲氨蝶呤毒性——病例系列及文献综述
Indian Dermatol Online J. 2024 Apr 29;15(3):473-479. doi: 10.4103/idoj.idoj_567_23. eCollection 2024 May-Jun.
6
Evaluation of toxicity after acute accidental methotrexate ingestions in children under 6 years old: a 16-year multi-center review.评价 6 岁以下儿童急性意外摄入甲氨蝶呤后的毒性:一项长达 16 年的多中心回顾研究。
Clin Toxicol (Phila). 2018 Feb;56(2):120-125. doi: 10.1080/15563650.2017.1349319. Epub 2017 Jul 21.
7
A Case Report on Iatrogenic Methotrexate Toxicity.一例医源性甲氨蝶呤中毒的病例报告。
Cureus. 2024 Jul 8;16(7):e64081. doi: 10.7759/cureus.64081. eCollection 2024 Jul.
8
Mucocutaneous ulcerations secondary to methotrexate.
Cutis. 2008 May;81(5):413-6.
9
Mucocutaneous Ulcerations and Pancytopenia due to Methotrexate Overdose.甲氨蝶呤过量导致的皮肤黏膜溃疡和全血细胞减少
Case Rep Dermatol. 2016 Nov 7;8(3):287-293. doi: 10.1159/000446692. eCollection 2016 Sep-Dec.
10
Acute mucocutaneous methotrexate toxicity associated with interface dermatitis and numerous eosinophils.与界面性皮炎和大量嗜酸性粒细胞相关的急性皮肤黏膜甲氨蝶呤毒性。
Am J Dermatopathol. 2013 Jun;35(4):e63-6. doi: 10.1097/DAD.0b013e31827b7674.

引用本文的文献

1
Mucocutaneous Adverse Effects of Methotrexate Toxicity: A Case Series.甲氨蝶呤毒性的皮肤黏膜不良反应:病例系列
JNMA J Nepal Med Assoc. 2025 Mar;63(283):189-194. doi: 10.31729/jnma.8905. Epub 2025 Mar 31.
2
Acute accidental methotrexate poisoning: Fatal consequences - An Indian experience.急性意外甲氨蝶呤中毒:致命后果——印度的经验
Indian J Pharmacol. 2025 May 1;57(3):196-199. doi: 10.4103/ijp.ijp_363_24. Epub 2025 Jul 9.
3
A Case Report on Iatrogenic Methotrexate Toxicity.一例医源性甲氨蝶呤中毒的病例报告。

本文引用的文献

1
What can clinicians learn from therapeutic studies about the treatment of acute oral methotrexate poisoning?临床医生可以从关于急性口服甲氨蝶呤中毒治疗的治疗性研究中学到什么?
Clin Toxicol (Phila). 2017 Feb;55(2):88-96. doi: 10.1080/15563650.2016.1271126.
2
Ulcerations due to methotrexate toxicity in a psoriasis patient.一名银屑病患者因甲氨蝶呤毒性导致的溃疡。
An Bras Dermatol. 2016 May-Jun;91(3):375-7. doi: 10.1590/abd1806-4841.20163960.
3
The possibilities and principles of methotrexate treatment of psoriasis - the updated knowledge.
Cureus. 2024 Jul 8;16(7):e64081. doi: 10.7759/cureus.64081. eCollection 2024 Jul.
4
Mucocutaneous Ulcers Unmasking Severe Systemic Methotrexate Toxicity - A Case-Series and Review of Literature.黏膜皮肤溃疡揭示严重的全身性甲氨蝶呤毒性——病例系列及文献综述
Indian Dermatol Online J. 2024 Apr 29;15(3):473-479. doi: 10.4103/idoj.idoj_567_23. eCollection 2024 May-Jun.
5
Low serum level and chronic toxicity for methotrexate. Case Report.甲氨蝶呤血清水平低与慢性毒性。病例报告。
Qatar Med J. 2023 Nov 13;2023(4):31. doi: 10.5339/qmj.2023.31. eCollection 2023.
6
Engineered biomaterial delivery strategies are used to reduce cardiotoxicity in osteosarcoma.工程化生物材料递送策略用于降低骨肉瘤中的心脏毒性。
Front Pharmacol. 2023 Oct 3;14:1284406. doi: 10.3389/fphar.2023.1284406. eCollection 2023.
7
Methotrexate-induced acute cardiotoxicity requiring veno-arterial extracorporeal membrane oxygenation support: a case report.甲氨蝶呤致急性心脏毒性需行血管-动脉体外膜肺氧合支持:病例报告。
J Med Case Rep. 2022 Nov 29;16(1):447. doi: 10.1186/s13256-022-03644-9.
8
A Fatal Fate: A Medical Error Leading to Acute Methotrexate Toxicity.致命的结局:导致急性甲氨蝶呤中毒的医疗差错
Cureus. 2022 Oct 25;14(10):e30659. doi: 10.7759/cureus.30659. eCollection 2022 Oct.
9
Advances in Cutaneous Squamous Cell Carcinoma Management.皮肤鳞状细胞癌治疗进展
Cancers (Basel). 2022 Jul 27;14(15):3653. doi: 10.3390/cancers14153653.
10
Modulation of Blood-Brain Barrier Permeability by Activating Adenosine A2 Receptors in Oncological Treatment.激活肿瘤治疗中的腺苷 A2 受体调节血脑屏障通透性。
Biomolecules. 2021 Apr 24;11(5):633. doi: 10.3390/biom11050633.
甲氨蝶呤治疗银屑病的可能性与原则——最新知识
Postepy Dermatol Alergol. 2014 Dec;31(6):392-400. doi: 10.5114/pdia.2014.47121. Epub 2014 Dec 3.
4
Cutaneous erosions: a herald for impending pancytopenia in methotrexate toxicity.皮肤糜烂:甲氨蝶呤毒性中即将出现全血细胞减少的先兆。
Dermatol Online J. 2014 Jul 15;20(7):13030/qt46k975h8.
5
Methotrexate toxicity during treatment of chronic plaque psoriasis: a case report and review of the literature.甲氨蝶呤治疗慢性斑块状银屑病时的毒性:病例报告及文献复习。
Dermatol Ther (Heidelb). 2014 Dec;4(2):145-56. doi: 10.1007/s13555-014-0056-z. Epub 2014 Jun 19.
6
Accidental high-dose methotrexate toxicity due to an electronic prescribing error.
Indian J Dermatol Venereol Leprol. 2014 May-Jun;80(3):268-9. doi: 10.4103/0378-6323.132264.
7
Methotrexate and trimethoprim-sulfamethoxazole: toxicity from this combination continues to occur.甲氨蝶呤与甲氧苄啶-磺胺甲恶唑:这种联合用药的毒性仍在不断出现。
Can Fam Physician. 2014 Jan;60(1):53-6.
8
Methotrexate-induced pulmonary toxicity.甲氨蝶呤所致肺毒性。
Can Respir J. 2013 May-Jun;20(3):153-5. doi: 10.1155/2013/527912.
9
Fatal methotrexate toxicity: could it have been avoided?致命的甲氨蝶呤毒性:本可避免吗?
BMJ Case Rep. 2013 Jun 12;2013:bcr2012008000. doi: 10.1136/bcr-2012-008000.
10
Methotrexate toxicity presenting as cutaneous ulcerations on psoriatic plaques.甲氨蝶呤毒性表现为银屑病斑块上的皮肤溃疡。
Cutan Ocul Toxicol. 2013 Oct;32(4):333-5. doi: 10.3109/15569527.2013.779278. Epub 2013 Mar 28.