一名银屑病患者因甲氨蝶呤毒性导致的溃疡。

Ulcerations due to methotrexate toxicity in a psoriasis patient.

作者信息

Souza Claudia Fernanda Dias, Suarez Olga Milena Zarco, Silva Talita Fonseca Medeiros da, Gorenstein Ana Carolina Lourenço Araújo, Quintella Leonardo Pereira, Avelleira João Carlos Regazzi

机构信息

Instituto de Dermatologia Professor Rubem David Azulay da Santa Casa da Misericórdia do Rio de Janeiro (IDPRDA/SCMRJ) - Rio de Janeiro (RJ), Brazil.

Fundação Oswaldo Cruz (FIOCRUZ) - Rio de Janeiro (RJ), Brazil.

出版信息

An Bras Dermatol. 2016 May-Jun;91(3):375-7. doi: 10.1590/abd1806-4841.20163960.

DOI:10.1590/abd1806-4841.20163960

PMID:27438211

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4938288/

Abstract

Methotrexate is one of the most used drugs in the treatment of psoriasis with indication of systemic therapy. Cutaneous and mucous side effects are described by pharmacological characteristics of the drug itself or due to overdose. We report the case of a patient with ulcerations in oral mucosa and psoriatic plaques after incorrect use of Methotrexate. Prescribed in a weekly dose, it was used continuously for 10 days and without simultaneous intake of folic acid. It is important to ensure correct comprehension of the prescription.

摘要

甲氨蝶呤是治疗银屑病时最常用的全身治疗药物之一。皮肤和黏膜副作用可由药物本身的药理学特性或过量使用引起。我们报告了1例患者在错误使用甲氨蝶呤后出现口腔黏膜溃疡和银屑病斑块的病例。该药物按每周剂量给药，连续使用了10天，且未同时服用叶酸。确保正确理解处方很重要。