Rivera Andrew, Raymond Mallory, Grobman Ariel, Abouyared Marianne, Angeli Simon I
Department of Otolaryngology University of Miami Miami Florida.
Department of Otolaryngology Emory University Atlanta Georgia U.S.A.
Laryngoscope Investig Otolaryngol. 2017 Apr 10;2(3):109-112. doi: 10.1002/lio2.68. eCollection 2017 Jun.
Facial nerve dysfunction can vary in severity and recovery is dependent on the character of the injury. N-acetyl-cysteine prevents oxidative stress and cellular damage, and its use in the setting of nerve dysfunction from crush injury has not yet been established. In this study, rats with facial nerve crush injury will be treated with n-acetyl-cysteine or control and functional recovery and electrophysiologic outcome will be compared.
Prospective, randomized animal study.
Twenty-four Wistar rats underwent unilateral facial nerve crush injury. Rats were implanted with a subcutaneous osmotic pump filled with saline (n = 12) or n-acetyl-cysteine 50 mg/kg/day (n = 12). Functional and electromyographic recovery was recorded at two and four weeks postoperatively.
When compared to untreated rats, n-acetyl-cysteine treated rats had a greater electromyography amplitude recovery at 2 weeks with regard to eye blink (p=0.006) but not vibrissae function. At four weeks, the electromyography amplitude recovery of the vibrissae function was greater in n-acetyl-cysteine treated rats (P=0.001), but the amplitude recovery difference in eye blink was only marginally significant between groups (p=0.07). The functional score was higher in n-acetyl-cysteine-treated rats than in untreated rats at all of the time points.
This study demonstrated that n-acetyl-cysteine facilitated facial nerve recovery with improved functional and electromyography outcomes in the setting of crush injury.
NA.
面神经功能障碍的严重程度各不相同，恢复情况取决于损伤的性质。N-乙酰半胱氨酸可预防氧化应激和细胞损伤，但其在挤压伤所致神经功能障碍中的应用尚未得到证实。在本研究中，将对患有面神经挤压伤的大鼠用N-乙酰半胱氨酸或对照进行治疗，并比较功能恢复情况和电生理结果。
前瞻性、随机动物研究。
24只Wistar大鼠接受单侧面神经挤压伤。给大鼠植入皮下渗透泵，其中填充生理盐水（n = 12）或50 mg/kg/天的N-乙酰半胱氨酸（n = 12）。在术后两周和四周记录功能和肌电图恢复情况。
与未治疗的大鼠相比，N-乙酰半胱氨酸治疗的大鼠在术后2周时眨眼的肌电图幅度恢复更好（p = 0.006），但触须功能方面没有差异。在四周时，N-乙酰半胱氨酸治疗的大鼠触须功能的肌电图幅度恢复更好（P = 0.001），但两组间眨眼幅度恢复差异仅边缘显著（p = 0.07）。在所有时间点，N-乙酰半胱氨酸治疗的大鼠功能评分均高于未治疗的大鼠。
本研究表明，在挤压伤情况下，N-乙酰半胱氨酸促进了面神经恢复，改善了功能和肌电图结果。
无。
