Vertes C, Gonczy S, Lendvay N, Debreczeni L A
Experimental Pathophysiological Research Unit, National Koranyi Institute for TBC and Pulmonology, Budapest, Hungary.
Bull Eur Physiopathol Respir. 1987;23 Suppl 10:111s-113s.
Guinea-pigs were sensitized with killed Bordetella pertussis (3.85 X 10(11) cells . kg-1). The presence of the immediate type of immune response was verified by passive cutaneous anaphylaxis (PCA). In anaesthetized spontaneously-breathing guinea-pigs respiration rate, tidal volume, minute ventilation, dynamic lung resistance and dynamic lung elastance were estimated on the basis of airflow velocity and pressure in the oesophagus. After provocation by a single intravenous injection of the killed cells, respiratory frequency, elastance and resistance increased but tidal volume decreased. The preventive effects of aminophylline and clemastine (50 microns . kg-1, i.v.) were observed. B. pertussis not only alters adrenergic function but provocation in B. pertussis-sensitized guinea-pigs seems to be a good model for bronchial asthma.
用灭活的百日咳博德特氏菌（3.85×10¹¹个细胞·kg⁻¹）对豚鼠进行致敏。通过被动皮肤过敏反应（PCA）验证即刻型免疫反应的存在。在麻醉的自主呼吸豚鼠中，根据食管中的气流速度和压力估算呼吸频率、潮气量、分钟通气量、动态肺阻力和动态肺弹性。在单次静脉注射灭活细胞进行激发后，呼吸频率、弹性和阻力增加，但潮气量减少。观察了氨茶碱和氯马斯汀（50微克·kg⁻¹，静脉注射）的预防作用。百日咳博德特氏菌不仅改变肾上腺素能功能，而且在百日咳博德特氏菌致敏的豚鼠中进行激发似乎是支气管哮喘的一个良好模型。
