Oddoy A, Jülich W D, Lachmann B, Müller E, Vogel J
Z Erkr Atmungsorgane. 1982;159(2):183-93.
45 guinea pigs sensitized to ovalbumin and 9 controls were challenged with antigenic aerosol. Before and during the challenge oesophageal pressure (Poes), airflow (V) and tidal volume (VT) were measured in anaesthetized (urethane) spontaneously breathing animals. Inspiratory and expiratory lung resistance (RI, RE) and dynamic lung compliance (Cdyn) were obtained according to the method of Neergard and Wirz. Total pulmonary resistance was calculated by different methods. 18 animals responded with a significant asthmatic reaction with an increase of expiratory resistance and a decrease of dynamic compliance. There exists a close hyperbolic relation between RE and Cdyn before and during the asthmatic reaction. The best parameter to characterize the strength of asthmatic response in the anaesthetized guinea pig is delta Poes/VT.
45只对卵清蛋白致敏的豚鼠和9只对照豚鼠接受了抗原气雾剂激发。在激发前和激发过程中，对麻醉（乌拉坦）下自主呼吸的动物测量食管压力（Poes）、气流（V）和潮气量（VT）。根据内尔加德和维尔茨的方法获得吸气和呼气肺阻力（RI、RE）以及动态肺顺应性（Cdyn）。通过不同方法计算总肺阻力。18只动物出现显著的哮喘反应，呼气阻力增加，动态顺应性降低。在哮喘反应之前和期间，RE和Cdyn之间存在密切的双曲线关系。表征麻醉豚鼠哮喘反应强度的最佳参数是ΔPoes/VT。
