巨噬细胞在发育中的大脑中生成周细胞。
Macrophages Generate Pericytes in the Developing Brain.
机构信息
Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Laboratory of Neurobiology, Federal University of São Paulo, São Paulo, SP, Brazil.
出版信息
Cell Mol Neurobiol. 2018 May;38(4):777-782. doi: 10.1007/s10571-017-0549-2. Epub 2017 Sep 11.
Abstract
Pericytes are defined by their anatomical location encircling blood vessels' walls with their long projections. The exact embryonic sources of cerebral pericytes remain poorly understood, especially because of their recently revealed diversity. Yamamoto et al. (Sci Rep 7(1):3855, 2017) using state-of-the-art techniques, including several transgenic mice models, reveal that a subpopulation of brain pericytes are derived from phagocytic macrophages during vascular development. This work highlights a new possible ancestor of brain pericytes. The emerging knowledge from this research may provide new approaches for the treatment of several neurodevelopmental disorders in the future.
摘要
周细胞位于血管壁周围，其长突起环绕血管。由于周细胞最近才被揭示出具有多样性，因此其确切的胚胎来源仍知之甚少。Yamamoto 等人（Sci Rep 7(1):3855, 2017）使用最先进的技术，包括几种转基因小鼠模型，揭示了血管发育过程中，一部分脑周细胞来源于吞噬性巨噬细胞。这项工作突出了脑周细胞的一个新的可能祖源。这项研究的新发现可能为未来治疗几种神经发育障碍提供新的方法。
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