Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Department of Dentistry, University of Taubaté, Taubaté, São Paulo, Brazil.
Stem Cells Transl Med. 2021 Mar;10(3):346-356. doi: 10.1002/sctm.20-0284. Epub 2020 Oct 28.
Niches are specialized tissue microenvironments that control stem cells functioning. The bone marrow mesenchymal stem cell niche defines a location within the marrow in which mesenchymal stem cells are retained and produce new cells throughout life. Deciphering the signaling mechanisms by which the niche regulates stem cell fate will facilitate the use of these cells for therapy. Recent studies, by using state-of-the-art methodologies, including sophisticated in vivo inducible genetic techniques, such as lineage-tracing Cre/loxP mediated systems, in combination with pharmacological inhibition, provide evidence that sensory neuron is an important component of the bone marrow mesenchymal stem cell niche. Strikingly, knockout of a specific receptor in sensory neurons blocked stem cell function in the bone marrow. The knowledge arising from these discoveries will be crucial for stem cell manipulation in the future. Here, we review recent progress in our understanding of sensory nerves biology in the stem cell niche.
龛位是控制干细胞功能的组织微环境。骨髓间充质干细胞龛位定义了骨髓内的一个位置，其中间充质干细胞被保留并在整个生命周期中产生新细胞。解析龛位调节干细胞命运的信号机制将有助于将这些细胞用于治疗。最近的研究使用了最先进的方法，包括复杂的体内诱导遗传技术，如谱系追踪 Cre/loxP 介导的系统，结合药理学抑制，提供了证据表明感觉神经元是骨髓间充质干细胞龛位的重要组成部分。引人注目的是，感觉神经元中特定受体的敲除阻断了骨髓中的干细胞功能。这些发现所带来的知识对于未来的干细胞操作至关重要。在这里，我们回顾了我们对感觉神经生物学在干细胞龛位中作用的最新理解。
