Department of Neurology, Laboratory for Neurotherapeutics, Comprehensive Epilepsy Center, Biomedical Research Institute, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, South Korea.
Department of Neurology, Kyung Hee University Hospital at Gangdong, Seoul, South Korea.
J Neurovirol. 2017 Dec;23(6):903-907. doi: 10.1007/s13365-017-0568-2. Epub 2017 Sep 11.
Parvovirus B19 (PVB19) has rarely been identified as a cause of encephalitis in immunocompetent adults, in whom clinical information regarding PVB19 encephalitis has remained unclear. Herein, we report the clinical presentations, laboratory and imaging findings, and treatment outcomes of five immunocompetent adults with PVB19 encephalitis. Although none of the patients showed any distinctive features of PVB19 infection, they showed various clinical manifestations, including one instance of brainstem involvement. Additionally, immunotherapy can be considered an effective approach, especially in immunocompetent adults with PVB19 encephalitis who are resistant to the initial management.
细小病毒 B19（PVB19）很少被确定为免疫功能正常成年人脑炎的病因，而关于 PVB19 脑炎的临床信息仍不清楚。在此，我们报告了五例免疫功能正常的成年人 PVB19 脑炎的临床表现、实验室和影像学检查结果以及治疗转归。尽管这些患者均无 PVB19 感染的特征性表现，但他们表现出各种临床表现，包括一例累及脑干的情况。此外，免疫疗法可以被认为是一种有效的治疗方法，尤其是对于最初治疗无效的免疫功能正常的成年人 PVB19 脑炎患者。
