Department of Pharmaceutics and Drug Delivery, The University of Mississippi, 113 Faser Hall, University, Mississippi, 38677, USA.
Institute for Drug Delivery and Biomedical Research, Bangalore, Karnataka, India.
AAPS PharmSciTech. 2018 Jan;19(1):27-35. doi: 10.1208/s12249-017-0865-3. Epub 2017 Sep 11.
The transdermal patch formulation has many advantages, including noninvasiveness, an ability to bypass the first-pass metabolism, low dosage requirements, and prolonged drug delivery. However, the instability of solid-state drugs is one of the most critical problems observed in transdermal patch products. Therefore, a well-characterized approach for counteracting stability problems in solid-state drugs is crucial for improving the performance of transdermal patch products. This review provides insight into the solid-state stability of drugs associated with transdermal patch products and offers a comprehensive update on the various approaches being used for improving the stability of the active pharmaceutical ingredients currently being used.
透皮贴剂制剂具有许多优点，包括非侵入性、能够绕过首过代谢、低剂量需求和延长药物输送。然而，固态药物的不稳定性是透皮贴剂产品中观察到的最关键问题之一。因此，对于改善透皮贴剂产品的性能，采取一种能够对抗固态药物稳定性问题的特征明确方法至关重要。本综述深入探讨了与透皮贴剂产品相关的药物固态稳定性，并全面更新了目前用于改善活性药物成分稳定性的各种方法。
