Walliczek-Dworschak Ute, Pellegrino Robert, Taube Franziska, Mueller Christian A, Stuck Boris Alexander, Dworschak Philipp, Güldner Christian, Steinbach Silke
Department of Otorhinolaryngology-Head and Neck Surgery, Philipps University Marburg, Marburg, Germany.
Smell and Taste Clinic, Department of Otorhinolaryngology, Dresden Technical University, Dresden, Germany.
Laryngoscope. 2018 Mar;128(3):E86-E90. doi: 10.1002/lary.26873. Epub 2017 Sep 12.
OBJECTIVES/HYPOTHESIS: Olfactory dysfunction is common among the general population, with chronic rhinosinusitis (CRS) as one of the leading causes. Patients affected by CRS often report changes in taste sensations; however, quantitative measurements have not been performed to date. Therefore, the present study aimed to investigate gustatory and olfactory function in CRS patients prior to and after multimodal treatment.
Prospective cohort study.
Twenty-one patients suffering from CRS with nasal polyps (14 male, seven female) with a mean age of 48 ± 15 years were included in the study. Chemosensory function was assessed prior to and approximately 190 days after multimodal treatment, which included endoscopic sinus surgery, oral antibiotics for 5 days, oral steroids for 12 days, and at least 6 weeks of topical nasal steroids. Olfactory function was tested with the Sniffin' Sticks test battery, whereas gustatory function was measured with taste strips. A clinically relevant change in olfactory function was defined as a change of ≥5 points in the threshold, discrimination, and identification scores.
Compared to normative data, patients baseline gustatory and olfactory function was impaired. After multimodal treatment, improvements were seen in olfactory function for eight patients (42%), remained stable in 10 patients (53%), and deteriorated in one patient (5%). Taste function remained unchanged following sinus surgery.
Patients suffering from CRS with polyps exhibit olfactory and taste dysfunctions. Multimodal treatment leads to an improvement in olfactory, but not gustatory functionality.
目的/假设：嗅觉功能障碍在普通人群中很常见，慢性鼻-鼻窦炎（CRS）是主要病因之一。CRS患者常报告味觉发生变化；然而，迄今为止尚未进行定量测量。因此，本研究旨在调查多模式治疗前后CRS患者的味觉和嗅觉功能。
前瞻性队列研究。
本研究纳入了21例患有鼻息肉的CRS患者（14例男性，7例女性），平均年龄为48±15岁。在多模式治疗前及治疗后约190天评估化学感觉功能，多模式治疗包括鼻内镜鼻窦手术、口服抗生素5天、口服类固醇12天以及至少6周的局部鼻用类固醇。嗅觉功能用嗅棒测试组进行测试，而味觉功能用味觉试纸进行测量。嗅觉功能的临床相关变化定义为阈值、辨别力和识别分数变化≥5分。
与标准数据相比，患者的基线味觉和嗅觉功能受损。多模式治疗后，8例患者（42%）的嗅觉功能有所改善，10例患者（53%）保持稳定，1例患者（5%）恶化。鼻窦手术后味觉功能保持不变。
患有鼻息肉的CRS患者存在嗅觉和味觉功能障碍。多模式治疗可改善嗅觉功能，但不能改善味觉功能。
4。《喉镜》，2018年，第128卷，E86-E90页。
