Institute of Chemistry and Biotechnology, Center for Organic and Medicinal Chemistry, Zurich University of Applied Sciences (ZHAW), Einsiedlerstrasse 31, 8820, Wädenswil, Switzerland.
Angew Chem Int Ed Engl. 2017 Oct 16;56(43):13184-13186. doi: 10.1002/anie.201708133. Epub 2017 Sep 12.
Seek, and ye shall find: After years of focusing research on synthetic antibiotics out of fear that all the useful natural ones had already been found, a novel antibacterial compound has been discovered through conventional microbial extract screening. The broad-spectrum nucleoside-analogue inhibitor pseudouridimycin is selective for bacterial RNA polymerase and elicits very low resistance rates.
寻找，便会发现：多年来，由于担心所有有用的天然抗生素都已被发现，人们一直专注于合成抗生素的研究，而通过常规微生物提取物筛选，一种新型抗菌化合物已被发现。广谱核苷类似物抑制剂 pseudouridimycin 对细菌 RNA 聚合酶具有选择性，并产生非常低的耐药率。
