Neoplasma. 2017;64(6):901-908. doi: 10.4149/neo_2017_612.
This study aimed to determine the value of HA/HAase for detecting bladder cancer on the basis of preceding statistical performance. PubMed, Springer Link, Web of Science and Cochrane Library were systematically searched to identify potentially relevant published articles by using the key words: "bladder cancer or bladder tumor or bladder carcinoma", "hyaluronic acid or hyaluronan", "hyaluronidase or HAase". The methodological quality of each study was assessed by QUADAS-2. According to the inclusive and exclusive criteria, 8 articles were identified and methodologically analyzed by STATA 12.0 software package.The results showed that the pooled sensitivity of HA and HAase was 0.832 (95% confidence interval [CI]: 0.798, 0.861) and 0.834 (95% CI: 0.756, 0.891) respectively, the pooled specificity was 0.886 (95% CI: 0.852, 0.913) and 0.860 (95% CI: 0.801, 0.904), and the area under the summary ROC cure (AUC) was 0.90 (95% CI: 0.87, 0.92) and 0.91 (95% CI: 0.88, 0.93), respectively. Simultaneously the diagnostic accuracy of the combination of HA and HAase showed that the pooled sensitivity was 0.908 (95% CI: 0.879, 0.931), the pooled specificity was 0.825 (95% CI: 0.789, 0.856) and AUC was 0.94 (95% CI: 0.91, 0.95), indicating a relatively higher accuracy than HA and HAase alone. This meta-analysis strongly suggests that HA/HAase could be used as biomarkers for the diagnosis of bladder cancer.
本研究旨在根据先前的统计性能，确定 HA/HAase 在膀胱癌检测中的价值。通过使用关键词“膀胱癌或膀胱肿瘤或膀胱癌”、“透明质酸或透明质酸盐”、“透明质酸酶或 HAase”，系统地在 PubMed、Springer Link、Web of Science 和 Cochrane Library 中搜索潜在相关的已发表文章，以识别潜在相关的已发表文章。使用 QUADAS-2 评估每项研究的方法学质量。根据纳入和排除标准，确定 8 篇文章，并使用 STATA 12.0 软件包进行方法学分析。结果表明，HA 和 HAase 的合并敏感性分别为 0.832（95%置信区间[CI]：0.798，0.861）和 0.834（95%CI：0.756，0.891），合并特异性分别为 0.886（95%CI：0.852，0.913）和 0.860（95%CI：0.801，0.904），汇总 ROC 曲线下面积（AUC）分别为 0.90（95%CI：0.87，0.92）和 0.91（95%CI：0.88，0.93）。同时，HA 和 HAase 联合检测的诊断准确性表明，合并敏感性为 0.908（95%CI：0.879，0.931），合并特异性为 0.825（95%CI：0.789，0.856），AUC 为 0.94（95%CI：0.91，0.95），表明准确性相对高于单独使用 HA 和 HAase。这项荟萃分析强烈表明，HA/HAase 可以用作膀胱癌诊断的生物标志物。
