School of Public Health, Jilin University, Changchun 130021, Jilin, China.
Molecules. 2017 Sep 12;22(9):1535. doi: 10.3390/molecules22091535.
Polyoxometalates (POMs) are inorganic clusters that possess potential anti-bacterial, anti-viral, and anti-tumor activities. Herein, the in vitro anti-proliferation activities of K[VO(H₂O)]∙6H₂O () have been investigated on the MCF-7 and MDA-MB-231 cell lines. The results indicated that could inhibit the proliferation of MCF-7 (IC, 11.95 μM at 48 h) in a dose-dependent manner compared to the positive control, 5-fluorouracil (5-Fu, < 0.05). The anti-proliferation activity of might be mediated by arrest of the MCF-7 cells in the G₂/M phase and induction of apoptosis and necrosis. Moreover, can effectively quench the fluorescence of DNA. The binding mode between them may be groove or outside stacking binding. can also effectively quench the intrinsic fluorescence of bovine serum albumin (BSA) and human serum albumin (HSA) via static quenching, and changed the conformation of BSA and HSA.
多金属氧酸盐（POMs）是无机簇合物，具有潜在的抗菌、抗病毒和抗肿瘤活性。本文研究了 K[VO(H₂O)]∙6H₂O（）对 MCF-7 和 MDA-MB-231 细胞系的体外增殖抑制活性。结果表明，与阳性对照 5-氟尿嘧啶（5-Fu，<0.05）相比，在浓度依赖性方式下， 可以抑制 MCF-7 细胞的增殖（48 h 时的 IC₅₀为 11.95 μM）。可能通过将 MCF-7 细胞阻滞在 G₂/M 期以及诱导细胞凋亡和坏死来发挥抗增殖活性。此外， 可以有效地猝灭 DNA 的荧光。它们之间的结合模式可能是沟槽或外部堆积结合。还可以通过静态猝灭有效地猝灭牛血清白蛋白（BSA）和人血清白蛋白（HSA）的固有荧光，并改变 BSA 和 HSA 的构象。
