Department of Orthopaedics and Trauma, Medical University of Graz, 8036 Graz, Austria.
Division of Oncology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria.
Int J Mol Sci. 2017 Sep 12;18(9):1960. doi: 10.3390/ijms18091960.
Soft tissue sarcomas (STS) constitute a rare tumour entity comprising over 50 histological subtypes. MicroRNAs (miRNAs) are short non-protein coding RNA molecules that regulate gene expression by targeting the 3'-untranslated region of messenger RNAs. They are involved in a variety of human diseases, including malignancies, such as endometrial cancer, osteosarcoma, bronchial carcinoma and breast cancer. In STS, various miRNAs are differentially expressed, thus contributing to development, progression and invasion. Therefore, the aim of the present review is to summarise current knowledge on the role of miRNAs in STS. Furthermore, the potential role of miRNAs as diagnostic, prognostic and predictive biomarkers is discussed.
软组织肉瘤（STS）是一种罕见的肿瘤实体，包含超过 50 种组织学亚型。微小 RNA（miRNA）是短的非编码 RNA 分子，通过靶向信使 RNA 的 3'非翻译区来调节基因表达。它们参与多种人类疾病，包括恶性肿瘤，如子宫内膜癌、骨肉瘤、支气管癌和乳腺癌。在 STS 中，各种 miRNA 表达不同，因此有助于其发展、进展和侵袭。因此，本综述的目的是总结 miRNA 在 STS 中的作用的现有知识。此外，还讨论了 miRNA 作为诊断、预后和预测生物标志物的潜在作用。
