色甘酸钠与β2激动剂在大鼠肺过敏反应中的协同活性。
Synergistic activity of sodium cromoglycate and beta 2-stimulants in rat lung anaphylaxis.
作者信息
Riley P A, Stevens M T, Mather M E, Eady R P
机构信息
Department of Immunology, Fisons plc, Loughborough, Leicestershire, England.
出版信息
Eur J Pharmacol. 1987 Sep 2;141(1):143-7. doi: 10.1016/0014-2999(87)90422-5.
PMID:2889607
Abstract
Using a model of passive anaphylactic bronchoconstriction in the rat, the combined inhibitory effects of sodium cromoglycate and the beta 2-adrenoceptor agonists fenoterol and salbutamol were shown to be synergistic. Synergism was most evident in animals strongly sensitised with relatively high levels of IgE antibodies, in which the individual drugs showed reduced potency.
摘要
在大鼠被动过敏性支气管收缩模型中，色甘酸钠与β2-肾上腺素能受体激动剂非诺特罗和沙丁胺醇的联合抑制作用表现为协同效应。协同作用在被相对高水平IgE抗体强烈致敏的动物中最为明显，在这些动物中，单一药物的效力降低。
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