Academy of Scientific & Innovative Research, CSIR-IHBT, Palampur, Himachal Pradesh, India.
Natural Product Chemistry and Process Development Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh, India.
Nat Prod Res. 2020 Jan;34(2):233-240. doi: 10.1080/14786419.2018.1527836. Epub 2019 Jan 12.
A new narciclasine glycoside, narciclasine-4---D-xylopyranoside () was characterised along with four known alkaloids pancratistatin (), 1--(3-hydroxybutyryl) pancratistatin (), vittatine (), 9--demethylgalanthine () from . Their structures were established on the basis of spectroscopic data analysis. The cytotoxic study of extract, fractions and isolated compounds against two human cancer cell lines (KB and SiHa) indicated the potential activity of extract and -butanol fraction due to presence of active alkaloids pancratistatin, 1--(3-hydroxybutyryl) pancratistatin, lycorine and haemanthamine.
从郁金香属植物中分离得到一个新的藜芦碱糖苷，藜芦碱-4---D-吡喃木糖苷（），以及四个已知的生物碱：藜芦碱（）、1--（3-羟基丁酰基）藜芦碱（）、石蒜裂碱（）、9--去甲基百合碱（）。根据光谱数据分析确定了它们的结构。提取物、馏分和分离化合物对两种人癌细胞系（KB 和 SiHa）的细胞毒性研究表明，由于存在活性生物碱藜芦碱、1--（3-羟基丁酰基）藜芦碱、石蒜碱和血根碱，提取物和正丁醇馏分具有潜在的活性。
