Department of Biology, McGill University, Montréal, QC, Canada.
Dev Cell. 2017 Sep 11;42(5):439-440. doi: 10.1016/j.devcel.2017.08.017.
mRNA localization often contributes to translational control. Reporting in Science, Moor et al. (2017) now show that many mRNAs and ribosomes are asymmetrically distributed along the apical-basal axis of enterocytes. Remarkably, when starved mice are fed, mRNAs encoding ribosomal proteins rapidly move to the ribosome-rich apical side to activate translation.
mRNA 的定位常常有助于翻译调控。Moor 等人在《科学》杂志上的报告（2017 年）现在表明，许多 mRNA 和核糖体沿着肠细胞的顶端-基底轴呈不对称分布。值得注意的是，当饥饿的小鼠进食时，编码核糖体蛋白的 mRNA 迅速移动到富含核糖体的顶端，以激活翻译。
