Meyer Hans-Jonas, Ziemann Oliver, Kornhuber Malte, Emmer Alexander, Quäschling Ulf, Schob Stefan, Surov Alexey
1 Department of Diagnostic Radiology, Martin-Luther University Halle-Wittenberg, Halle, Germany.
2 Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany.
Acta Radiol. 2018 Jun;59(6):694-699. doi: 10.1177/0284185117731448. Epub 2017 Sep 12.
Background Magnetic resonance imaging (MRI) is widely used in several muscle disorders. Diffusion-weighted imaging (DWI) is an imaging modality, which can reflect microstructural tissue composition. The apparent diffusion coefficient (ADC) is used to quantify the random motion of water molecules in tissue. Purpose To investigate ADC values in patients with myositis and non-inflammatory myopathy and to analyze possible associations between ADC and laboratory parameters in these patients. Material and Methods Overall, 17 patients with several myositis entities, eight patients with non-inflammatory myopathies, and nine patients without muscle disorder as a control group were included in the study (mean age = 55.3 ± 14.3 years). The diagnosis was confirmed by histopathology in every case. DWI was obtained in a 1.5-T scanner using two b-values: 0 and 1000 s/mm. In all patients, the blood sample was acquired within three days to the MRI. The following serological parameters were estimated: C-reactive protein, lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, creatine kinase, and myoglobine. Results The estimated mean ADC value for the myositis group was 1.89 ± 0.37 × 10mm/s and for the non-inflammatory myopathy group was 1.79 ± 0.33 × 10 mm/s, respectively. The mean ADC values (1.15 ± 0.37 × 10 mm/s) were significantly higher to unaffected muscles (vs. myositis P = 0.0002 and vs. myopathy P = 0.0021). There were no significant correlations between serological parameters and ADC values. Conclusion Affected muscles showed statistically significantly higher ADC values than normal muscles. No linear correlations between ADC and serological parameters were identified.
背景磁共振成像（MRI）广泛应用于多种肌肉疾病。扩散加权成像（DWI）是一种成像方式，可反映组织的微观结构组成。表观扩散系数（ADC）用于量化组织中水分子的随机运动。目的研究肌炎和非炎性肌病患者的ADC值，并分析这些患者中ADC与实验室参数之间的可能关联。材料与方法本研究共纳入17例患有多种肌炎实体的患者、8例非炎性肌病患者以及9例无肌肉疾病的患者作为对照组（平均年龄=55.3±14.3岁）。每例患者均通过组织病理学确诊。在1.5-T扫描仪上使用两个b值（0和1000 s/mm²）进行DWI检查。所有患者在MRI检查前三天内采集血样。检测以下血清学参数：C反应蛋白、乳酸脱氢酶、谷丙转氨酶、谷草转氨酶、肌酸激酶和肌红蛋白。结果肌炎组的平均ADC值估计为1.89±0.37×10⁻³mm²/s，非炎性肌病组为1.79±0.33×10⁻³mm²/s。平均ADC值（1.15±0.37×10⁻³mm²/s）显著高于未受影响的肌肉（与肌炎相比P=0.0002，与肌病相比P=0.0021）。血清学参数与ADC值之间无显著相关性。结论受影响的肌肉显示出在统计学上显著高于正常肌肉的ADC值。未发现ADC与血清学参数之间存在线性相关性。
