Weger Meltem, Diotel Nicolas, Dorsemans Anne-Claire, Dickmeis Thomas, Weger Benjamin D
Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, United Kingdom.
Université de La Réunion, INSERM, UMR 1188, Diabète athérothrombose Thérapies Réunion Océan Indien (DéTROI), Saint-Denis de La Réunion, France.
Dev Biol. 2017 Nov 15;431(2):111-123. doi: 10.1016/j.ydbio.2017.09.012. Epub 2017 Sep 9.
The circadian timing system is a complex biological network of interacting circadian clocks that regulates 24h rhythms of behavioral and physiological processes. One intriguing observation is that stem cell homeostasis is subject to circadian clock regulation. Rhythmic oscillations have been observed in a variety of embryonic and adult stem cell dependent processes, such as hematopoietic progenitor cell migration, the hair follicle cycle, bone remodeling, regenerative myogenesis and neurogenesis. This review aims to discuss the nature of the circadian clock in embryonic stem cells and how it changes during differentiation. Furthermore, it will examine how the circadian clock contributes to adult stem cell function in different tissues of the body with an emphasis on the brain and adult neurogenesis.
昼夜节律系统是一个由相互作用的昼夜节律时钟组成的复杂生物网络，它调节行为和生理过程的24小时节律。一个有趣的观察结果是，干细胞稳态受昼夜节律时钟调控。在多种依赖胚胎和成年干细胞的过程中都观察到了节律性振荡，如造血祖细胞迁移、毛囊周期、骨重塑、再生性肌生成和神经发生。本综述旨在讨论胚胎干细胞中昼夜节律时钟的本质及其在分化过程中的变化。此外，还将研究昼夜节律时钟如何促进身体不同组织中的成体干细胞功能，重点是大脑和成年神经发生。
