Coghlan J G, Gilligan D, Humphries H, McKenna D, Dooley C, Sweeney E, Keane C, O'Morain C
Department of Gastroenterology, Meath, Adelaide.
Lancet. 1987 Nov 14;2(8568):1109-11. doi: 10.1016/s0140-6736(87)91545-5.
In 39 patients with endoscopically healed duodenal ulcers repeat endoscopy and two antral biopsies after 1 year showed a relapse rate of 59%. Only post-treatment Campylobacter pylori status was a significant predictor of endoscopic relapse. 79% of patients who remained culture positive had a relapse, compared with 27% of culture-negative patients. Relapse was more likely (66%) in patients with a recurrence of C pylori after apparent eradication of the organism than in those who remained negative for C pylori (10%). No patient who remained negative for C pylori had histological gastritis, whereas all with recurrence of C pylori showed histological gastritis. These findings suggest an important role for C pylori in duodenal ulcer relapse in the year after treatment.
在39例十二指肠溃疡经内镜检查已愈合的患者中，1年后重复内镜检查及两次胃窦活检显示复发率为59%。仅治疗后幽门螺杆菌状态是内镜复发的显著预测因素。培养仍为阳性的患者中有79%复发，而培养阴性的患者复发率为27%。在幽门螺杆菌明显根除后又复发的患者中，复发可能性更大（66%），而幽门螺杆菌仍为阴性的患者复发率为10%。幽门螺杆菌仍为阴性的患者均无组织学胃炎，而所有幽门螺杆菌复发的患者均有组织学胃炎。这些发现提示幽门螺杆菌在治疗后1年内十二指肠溃疡复发中起重要作用。
