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食管鳞状细胞癌中的染色体和基因组变异：技术、应用及展望综述

Chromosomal and Genomic Variations in Esophageal Squamous Cell Carcinoma: A Review of Technologies, Applications, and Prospections.

作者信息

Song Qi, Jiang Dongxian, Wang Haixing, Huang Jie, Liu Yalan, Xu Chen, Hou Yingyong

机构信息

Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.

Department of Pathology, School of Basic Medical Sciences & Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.

出版信息

J Cancer. 2017 Aug 2;8(13):2492-2500. doi: 10.7150/jca.19601. eCollection 2017.

DOI:10.7150/jca.19601
PMID:28900487
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5595079/
Abstract

Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors with poor prognosis worldwide. The poor prognosis is due to the advanced stage at the time of diagnosis and the limited clinical staging lacking significant molecular biomarkers to effectively stratify patients for treatment options. As cancer is a disease of genome instability and a resulting of accumulation of genetic alteration, mounting chromosomal and genomic technologies were developed and progressed rapidly which could be used for characterizing patients in genomics level. In this review, we summarized applications of multiple technologies and research progress at chromosomal and genomic level in ESCC.

摘要

食管鳞状细胞癌（ESCC）是全球最常见且预后较差的恶性肿瘤之一。预后差的原因在于诊断时已处于晚期，且临床分期有限，缺乏有效的分子生物标志物来为患者治疗方案进行有效分层。由于癌症是一种基因组不稳定的疾病，是基因改变积累的结果，因此大量染色体和基因组技术得以开发并迅速发展，可用于在基因组水平上对患者进行特征描述。在本综述中，我们总结了多种技术在ESCC染色体和基因组水平上的应用及研究进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b45b/5595079/6cd54e0c09c2/jcav08p2492g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b45b/5595079/ae5b4a7854c5/jcav08p2492g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b45b/5595079/26e2fb55747f/jcav08p2492g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b45b/5595079/6cd54e0c09c2/jcav08p2492g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b45b/5595079/ae5b4a7854c5/jcav08p2492g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b45b/5595079/26e2fb55747f/jcav08p2492g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b45b/5595079/6cd54e0c09c2/jcav08p2492g003.jpg

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Am J Hum Genet. 2016 Apr 7;98(4):709-27. doi: 10.1016/j.ajhg.2016.02.021.
3
Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population.日本人群食管鳞癌的基因组特征。
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World J Gastroenterol. 2024 May 28;30(20):2638-2656. doi: 10.3748/wjg.v30.i20.2638.
4
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5
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