Department of Anesthesiology, LSU Health Sciences Center, Room 656, 1542 Tulane Ave., New Orleans, LA, 70112, USA.
VCU, Department of Anesthesiology, 1200 East Broad Street, 7th Floor, PO Box 980695, Richmond Virginia, 23298, USA.
Best Pract Res Clin Anaesthesiol. 2018 Jun;32(2):61-81. doi: 10.1016/j.bpa.2018.07.001. Epub 2018 Aug 6.
The study of how individual genetic differences, known as polymorphisms, change the pharmacokinetics and pharmacodynamics of drugs is called pharmacogenomics. As the field of pharmacogenetics grows and continues to identify genetic polymorphisms, it is promising that the unmet need in this patient population may soon be addressed with personalized drug therapy based on the patient's genetic composition. Although encouraging, pharmacogenomic testing is underutilized in the United States and is often not covered by insurance companies. This manuscript describes the current state of precision medicine as it relates to perioperative care and how preoperative genomic analysis can help improve patient outcomes. This investigation also outlines future directions in this important and evolving field.
个体遗传差异（称为多态性）如何改变药物的药代动力学和药效学的研究称为药物基因组学。随着药物遗传学领域的发展并继续鉴定遗传多态性，有希望的是，基于患者的遗传构成，针对患者的个性化药物治疗可能很快就能满足这一患者群体的未满足需求。尽管令人鼓舞，但药物基因组学检测在美国的利用率较低，并且通常不在保险公司的承保范围内。本文描述了与围手术期护理相关的精准医学的现状，以及术前基因组分析如何有助于改善患者的预后。本研究还概述了这一重要且不断发展的领域的未来方向。
