A retrospective analysis of the efficacy of microparticle-mediated chemoembolization in liver metastases arising from gastrointestinal tumors.

作者信息

Li Chuang, Liu Ying, Zhou Jun, Zhang Yue-Wei

机构信息

Department of Intervention, The Affiliated Zhongshan Hospital of Dalian University, Dalian, China.

Department of Hepatopancreatobiliary Interventional Radiology, Beijing Tsinghua Changgeng Hospital, Beijing, China.

出版信息

J Cancer Res Ther. 2017;13(4):642-646. doi: 10.4103/jcrt.JCRT_213_17.

PURPOSE

We evaluated the clinical efficacy of gelatin sponge microparticle (GSM) -mediated chemoembolization for the treatment of patients with liver metastases following surgery for gastrointestinal tumors.

MATERIALS AND METHODS

In a retrospective analysis of 37 patients who were treated at our hospital with GSM-mediated chemoembolization for liver metastases over 13 years, we evaluated outcomes using a modified response evaluation criteria in solid tumors system and also assessed liver function and adverse effects. All patients had previously undergone surgery for gastrointestinal tumors.

RESULTS

Treatment produced various degrees of necrosis and shrinkage of lesions among our patients. Two patients achieved a complete response (CR), 27 showed a partial response (PR), five had stable disease, and three had progressive disease. The overall response rate (CR + PR) was 78%, and no severe adverse effects were observed.

CONCLUSION

GSM-mediated chemoembolization showed good clinical efficacy in the treatment of liver metastases after gastrointestinal tumor surgery. However, larger cohort and clinical controlled studies are warranted.