Therasse E, Breittmayer F, Roche A, De Baere T, Indushekar S, Ducreux M, Lasser P, Elias D, Rougier P
Department of Interventional Radiology, Institut Gustave Roussy, Villejuif, France.
Radiology. 1993 Nov;189(2):541-7. doi: 10.1148/radiology.189.2.7692465.
The authors report their experience treating progressive liver metastases from carcinoid tumor with doxorubicin, iodized oil, and gelatin sponge embolization.
Of 23 patients, 18 had carcinoid syndrome and 19 had elevated urinary 5-hydroxyindoleacetic acid (5-HIAA) levels. Relief of symptoms, changes in 5-HIAA levels, and changes in tumor size could be evaluated in 10, 11, and 17 patients, respectively.
Symptomatic response was complete (average duration, 29 months) in 70% and partial in 30% of evaluated patients. Biologic response was complete (average duration, 21 months) in 73%, partial in 18%, and minor in 9% of evaluated patients. Morphologic response was complete in 11%, partial in 24%, and minor in 24% of evaluated patients. Survival after diagnosis of primary tumor, diagnosis of hepatic metastases, and first chemoembolization was 81, 47, and 24 months, respectively. Eight patients were alive at the end of the study. No mortality was related to chemoembolization.
Chemoembolization is safe and effective for palliation of carcinoid liver metastases.
作者报告了他们用阿霉素、碘化油和明胶海绵栓塞治疗类癌肿瘤进展性肝转移的经验。
23例患者中，18例有类癌综合征，19例尿5-羟吲哚乙酸（5-HIAA）水平升高。分别对10例、11例和17例患者评估了症状缓解情况、5-HIAA水平变化和肿瘤大小变化。
在评估的患者中，70%的患者症状完全缓解（平均持续时间29个月），30%部分缓解。在评估的患者中，73%的患者生物学反应完全缓解（平均持续时间21个月），18%部分缓解，9%轻微缓解。在评估的患者中，11%的患者形态学反应完全缓解，24%部分缓解，24%轻微缓解。原发性肿瘤诊断后、肝转移诊断后和首次化疗栓塞后的生存期分别为81个月、47个月和24个月。研究结束时8例患者存活。无死亡与化疗栓塞相关。
化疗栓塞治疗类癌肝转移安全有效。
