hst的基因组序列，hst是一个转化基因，编码一种与成纤维细胞生长因子及int-2编码蛋白同源的蛋白质。
Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein.
作者信息
Yoshida T, Miyagawa K, Odagiri H, Sakamoto H, Little P F, Terada M, Sugimura T
机构信息
Genetics Division, National Cancer Center Research Institute, Tokyo, Japan.
出版信息
Proc Natl Acad Sci U S A. 1987 Oct;84(20):7305-9. doi: 10.1073/pnas.84.20.7305.
Abstract
hst is a transforming gene first identified from transformed NIH 3T3 cells that were transfected with DNA of a human stomach cancer. A genomic fragment of hst obtained directly from a human genomic library also has transforming activity. This fragment has a coding sequence identical to that of the hst cDNA prepared from an NIH 3T3 transformant induced by DNA from a stomach cancer. The deduced amino acid sequence of the hst protein is 43%, 38%, and 40% homologous, respectively, to human basic fibroblast growth factor, human acidic fibroblast growth factor, and mouse int-2 protein in selected regions. This suggests that hst encodes a protein related to fibroblast growth factors, which are wide-spectrum mitogens, and to the int-2 protein, a potential oncogene product implicated in murine mammary carcinogenesis.
摘要
hst是一种转化基因，最初是从用人类胃癌DNA转染的转化NIH 3T3细胞中鉴定出来的。直接从人类基因组文库获得的hst基因组片段也具有转化活性。该片段的编码序列与从胃癌DNA诱导的NIH 3T3转化体中制备的hst cDNA的编码序列相同。hst蛋白的推导氨基酸序列在选定区域分别与人碱性成纤维细胞生长因子、人酸性成纤维细胞生长因子和小鼠int-2蛋白有43%、38%和40%的同源性。这表明hst编码一种与成纤维细胞生长因子相关的蛋白质，成纤维细胞生长因子是广谱促有丝分裂原，并且与int-2蛋白相关，int-2蛋白是一种潜在的癌基因产物，与小鼠乳腺癌发生有关。
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